Giancarlo Castaman
University of Florence
435 Papers
3.6K Citations
Giancarlo Castaman is an academic researcher from University of Florence. The author has contributed to research in topics: Medicine & Von Willebrand disease. The author has an hindex of 60, co-authored 389 publications. Previous affiliations of Giancarlo Castaman include UniFi & University of Milan.
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Papers
Prophylaxis with recombinant von Willebrand factor in patients with type 3 von Willebrand disease: Results of a post hoc analysis from a phase 3 trial
Frank W.G. Leebeek,Flora Peyvandi,Andreas Tiede,Giancarlo Castaman,Miguel Pimienta Escobar,Michael Wang,Bülent Zülfikar,Sophie Susen,Wolfgang Miesbach,Scarlett Wang,Yi Wang,Jingmei Zhang,Gülden Özen +12 more
TL;DR: In this article , the efficacy/safety of recombinant von Willebrand factor (rVWF) prophylaxis in patients with type 3 vonWillebrand disease (VWD) was described.
Clinical manifestations and management of Gaucher disease.
Silvia Linari,Giancarlo Castaman +1 more
TL;DR: Enzyme replacement therapy has been shown to be effective in reducing glucocerebroside storage burden and diminishing the deleterious effects caused by its accumulation.
Specific factor IX mRNA and protein features favor drug-induced readthrough over recurrent nonsense mutations.
Alessio Branchini,Mattia Ferrarese,Matteo Campioni,Giancarlo Castaman,Rosella Mari,Francesco Bernardi,Mirko Pinotti +6 more
TL;DR: This rational approach, applicable to other coagulation disorders, helps with interpreting the poor response reported in the few investigated HB patients, and identifies candidate patients eligible for treatment.
Severe bleeding and absent ADP-induced platelet aggregation associated with inherited combined CalDAG-GEFI and P2Y12 deficiencies.
Barbara Lunghi,Anna Lecchi,Rosa Santacroce,Mariangela Scavone,Rita Paniccia,Andrea Artoni,Christian Gachet,Giancarlo Castaman,Maurizio Margaglione,Francesco Bernardi,Marco Cattaneo +10 more
TL;DR: Inherited platelet function disorders are associated with a heightened risk for mucocutaneous bleeding of variable severity and excessive hemorrhage after surgery or trauma and abnormalities of receptors for adhesive proteins or soluble agonists.
Prospective multicenter study on subcutaneous concentrated desmopressin for home treatment of patients with von Willebrand disease and mild or moderate hemophilia A.
TL;DR: Home therapy with subcutaneous desmopressin for von Willebrand disease and hemophilia A was well accepted by the patients and proved feasible, efficacious and safe for the prevention or prompt treatment of bleeding.