Gesche Weppner
University of Lübeck
2 Papers
Gesche Weppner is an academic researcher from University of Lübeck. The author has contributed to research in topics: Proteinase 3 & Granulomatosis with polyangiitis. The author has an hindex of 2, co-authored 2 publications.
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Papers
In situ detection of PR3-ANCA+ B cells and alterations in the variable region of immunoglobulin genes support a role of inflamed tissue in the emergence of auto-reactivity in granulomatosis with polyangiitis.
Gesche Weppner,Olena Ohlei,Christoph M. Hammers,Konstanze Holl-Ulrich,Jan Voswinkel,Julia Bischof,Katrin Hasselbacher,Gabriela Riemekasten,Peter Lamprecht,Saleh M. Ibrahim,C. Iking-Konert,Andreas Recke,Antje Müller +12 more
TL;DR: The results suggest that with respect to a local anti-PR3 response, methods detecting rare clones are required, and primary and probably secondary rearrangements led to altered VDJ usage and an extended complementarity determining region 3 (CDR3) of IGHV clones from GPA tissue.
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Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides.
Peter Lamprecht,Anja Kerstein,Sebastian Klapa,Susanne Schinke,Christian M. Karsten,Xinhua Yu,Marc Ehlers,Jörg T. Epplen,Konstanze Holl-Ulrich,Thorsten Wiech,Kathrin Kalies,Tanja Lange,Martin Laudien,Tamás Laskay,Timo Gemoll,Udo Schumacher,Sebastian Ullrich,Hauke Busch,Saleh M. Ibrahim,Nicole Fischer,Katrin Hasselbacher,Ralph Pries,Frank Petersen,Gesche Weppner,Rudolf A. Manz,Jens Y Humrich,Relana Nieberding,Gabriela Riemekasten,Antje Müller +28 more
TL;DR: This review gives a brief overview on current knowledge about genetic and epigenetic factors, barrier dysfunction and chronic non-resolving inflammation, necro-inflammatory auto-amplification of cellular death and inflammation, altered autoantigen presentation, alternative complement pathway activation, alterations within peripheral and inflamed tissue-residing T- and B-cell populations, ectopic lymphoid tissue neoformation, the characterization of PR3-specific T-cells, properties of ANCA.