Gerry Stephen Oxford
Indiana University
19 Papers
87 Citations
Gerry Stephen Oxford is an academic researcher from Indiana University. The author has contributed to research in topics: Trigeminovascular system & Sensitization. The author has an hindex of 12, co-authored 19 publications.
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Papers
Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex
Joel M. Brittain,Djane B. Duarte,Sarah M. Wilson,Weiguo Zhu,Carrie J. Ballard,Philip L. Johnson,Nai-Kui Liu,Wenhui Xiong,Matthew S. Ripsch,Yuying Wang,Jill C. Fehrenbacher,Stephanie D. Fitz,May Khanna,Chul Park,Brian S. Schmutzler,Bo M. Cheon,Michael R. Due,Tatiana Brustovetsky,Nicole M. Ashpole,Andy Hudmon,Samy O. Meroueh,Cynthia M. Hingtgen,Nickolay Brustovetsky,Ru-Rong Ji,Joyce H. Hurley,Xiaoming Jin,Anantha Shekhar,Xiao Ming Xu,Gerry Stephen Oxford,Michael R. Vasko,Fletcher A. White,Rajesh Khanna +31 more
TL;DR: By preventing CRMP-2–mediated enhancement of CaV2.2 function, TAT-CBD3 alleviated inflammatory and neuropathic hypersensitivity, an approach that may prove useful in managing chronic pain.
NPY Y1 receptors differentially modulate GABAA and NMDA receptors via divergent signal-transduction pathways to reduce excitability of amygdala neurons.
Andrei I Molosh,Tammy J. Sajdyk,Tammy J. Sajdyk,William A. Truitt,Weiguo Zhu,Gerry Stephen Oxford,Anantha Shekhar +6 more
TL;DR: NPY regulates amygdala excitability via two signal-transduction events, with reduced PKA activity enhancing GABAA-mediated eIPSCs and Epac deactivation reducing NMDA- mediated eEPSCs, which may be important for NPY plasticity and stress resilience in the amygdala.
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D2 dopamine receptor activation of potassium channels is selectively decoupled by Gαi-specific GoLoco motif peptides
Christina K. Webb,Christina K. Webb,Christopher R. McCudden,Francis S. Willard,Randall J. Kimple,David P. Siderovski,Gerry Stephen Oxford +6 more
TL;DR: GoLoco motif‐based peptides will be useful tools in examining the specificity of G‐protein‐coupled receptor–effector coupling, and have no effect on either basal channel activity or the initial responses to agonists, suggesting that the Go loco motif cannot disrupt pre‐formed G‐ protein heterotrimers.
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Differential gene expression of neonatal and adult DRG neurons correlates with the differential sensitization of TRPV1 responses to nerve growth factor.
Weiguo Zhu,Gerry Stephen Oxford +1 more
TL;DR: Higher adult neuron expression of ERK1/2, PI3K/P110α, but not of TRPV1 and TrkA, was found and confirmed by PCR and western blot, consistent with the key role of ERk and PI3k signaling in sensitization of TRpV1 by NGF and may explain the previously published observation that adult, butNot neonatal, rat DRG neurons are sensitized by N GF.
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Role of intraganglionic transmission in the trigeminovascular pathway.
TL;DR: Data suggest an important role for intraganglionic transmission in acute activation of the trigeminovascular pathway and supports a role for upregulation of TRPA1 receptors in peripheral sensitization and a possible mechanism for chronification of migraine after environmental irritant exposure.
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