Gergely Tóth
Creighton University
17 Papers
354 Citations
Gergely Tóth is an academic researcher from Creighton University. The author has contributed to research in topics: Side chain & Parkin. The author has an hindex of 9, co-authored 17 publications. Previous affiliations of Gergely Tóth include University of Nottingham.
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Papers
On the Mechanism of Nonspecific Inhibitors of Protein Aggregation: Dissecting the Interactions of α-Synuclein with Congo Red and Lacmoid
Christofer Lendel,Carlos W. Bertoncini,Nunilo Cremades,Christopher A. Waudby,Michele Vendruscolo,Christopher M. Dobson,Dale Schenk,John Christodoulou,John Christodoulou,Gergely Tóth +9 more
TL;DR: The mechanisms of interaction between alpha-synuclein, a protein whose aggregation is closely connected with Parkinson's disease, and two small molecules, Congo red and Lacmoid, which inhibit its fibrillization are characterized.
Significance of aromatic-backbone amide interactions in protein structure
TL;DR: The analyses of the secondary structures of the protein fragments containing Ar–HN interactions showed that Ar–hN interactions were in all types of secondary structures, and search results suggest that Ar-HN interaction have a stabilizing effect on all typesof secondary structures.
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Flap opening mechanism of HIV-1 protease.
Gergely Tóth,Attila Borics +1 more
TL;DR: The mechanism of flap opening and the structure and dynamics of HIV-1 PR with semi- open and open flap conformations were investigated using molecular dynamics simulations and a network of weakly polar interactions between the flaps were proposed to be responsible for stabilizing the semi-open flap conformation.
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Stabilization of local structures by π–CH and aromatic–backbone amide interactions involving prolyl and aromatic residues
TL;DR: In this paper, a database search was performed in a non-redundant set of proteins from the Brookheaven Protein Data Bank for pi-CH and Ar-HN interactions in Pro-Xaa and Xaa-Pro fragments (where Xaa is either Phe, Tyr or Trp).
Closing of the flaps of HIV-1 protease induced by substrate binding: a model of a flap closing mechanism in retroviral aspartic proteases.
Gergely Tóth,Attila Borics +1 more
TL;DR: The flap closing mechanism described in HIV-1 PR is proposed to be a general model for flap closing in retroviral aspartic proteases.
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