Gerd A. Kullak-Ublick
University of Zurich
256 Papers
1.4K Citations
Gerd A. Kullak-Ublick is an academic researcher from University of Zurich. The author has contributed to research in topics: Medicine & Bile acid. The author has an hindex of 61, co-authored 245 publications. Previous affiliations of Gerd A. Kullak-Ublick include Novartis & National Patient Safety Foundation.
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Papers
Quantification of multiple bile acids in uninephrectomized rats using ultra-performance liquid chromatography-tandem mass spectrometry
Carlos A. Penno,Carlos A. Penno,Denis Arsenijevic,Thierry Da Cunha,Gerd A. Kullak-Ublick,Jean-Pierre Montani,Alex Odermatt +6 more
TL;DR: An ultra-performance liquid chromatography tandem mass spectrometry method that allows the simultaneous quantification of multiple BAs in 50 μL serum or plasma samples, and can be used to assess BA profiles in patho-physiological situations, is developed and validated.
Gastric pharmacobezoars in quetiapine extended-release overdose: A case series
Christine Rauber-Lüthy,Katharina E. Hofer,Michael Bodmer,Gerd A. Kullak-Ublick,Hugo Kupferschmidt,Alessandro Ceschi +5 more
TL;DR: The possibility of pharmacobezoar formation following a large quetiapine XR overdose should be considered, as this may influence acute patient management.
Microlithiasis and sludge
TL;DR: 'Sludge' is the solid material which results from the slow settling of particles dispersed in a liquid medium, and microlithiasis and sludge in bile may cause colicky pain, cholecystitis, cholangitis, and acute pancreatitis and are thus of clinical relevance.
Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy
Christiane Pauli-Magnus,Thomas Lang,Yvonne Meier,Tina Zodan-Marin,Diana Jung,Christian Breymann,Roland Zimmermann,Silke Kenngott,Ulrich Beuers,Christoph Reichel,Reinhold Kerb,Anja Penger,Peter J. Meier,Gerd A. Kullak-Ublick +13 more
TL;DR: The data further support an involvement of MDR3 genetic variation in the pathogenesis of ICP, whereas analysis of BSEP sequence variation indicates that this gene is probably less important for the development of pregnancy-associated cholestasis.
Medical Treatment of Primary Sclerosing Cholangitis: A Role for Novel Bile Acids and other (post-)Transcriptional Modulators?
TL;DR: In the view, the novel bile acid norUDCA and agonists of PPARs, VDR, and PXR appear particularly attractive for further studies in PSC, and their pros and cons are discussed in detail.