Gerd A. Kullak-Ublick
University of Zurich
256 Papers
1.4K Citations
Gerd A. Kullak-Ublick is an academic researcher from University of Zurich. The author has contributed to research in topics: Medicine & Bile acid. The author has an hindex of 61, co-authored 245 publications. Previous affiliations of Gerd A. Kullak-Ublick include Novartis & National Patient Safety Foundation.
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Papers
Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice.
TL;DR: Investigation of the protective role of FXR against kidney damage induced by obesity in mice that had undergone uninephrectomy found that FXR activation maintains endogenous glutathione homeostasis and protects the kidney in uninePhrectomized mice from obesity-induced injury.
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Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy.
Michael Scharl,Jessica Mwinyi,Anne Fischbeck,Katharina Leucht,Jyrki J. Eloranta,Joba M. Arikkat,Theresa Pesch,Silvia Kellermeier,Alma Mair,Gerd A. Kullak-Ublick,Kaspar Truninger,Faiza Noreen,Jaroslaw Regula,Pawel Gaj,Valérie Pittet,Christoph Mueller,Claudia Hofmann,Michael Fried,Declan F. McCole,Gerhard Rogler +19 more
TL;DR: These findings not only provide key insights into the effects of a functional mutation on a clinically relevant gene, but also reveal how such a mutation could contribute to the onset of disease.
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Vitamin D3 and Its Nuclear Receptor Increase the Expression and Activity of the Human Proton-Coupled Folate Transporter
Jyrki J. Eloranta,Zoulikha M. Zaïr,Christian Hiller,Stephanie Häusler,Bruno Stieger,Gerd A. Kullak-Ublick +5 more
TL;DR: Functional support of this regulatory mechanism, treatment with vitamin D3 significantly increased the uptake of [3H]folic acid into Caco-2 cells at pH 5.5, resulting in enhanced cellular folate uptake.
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Bile acids in drug induced liver injury: Key players and surrogate markers
Heiko Schadt,Armin Wolf,Francois Pognan,Salah-Dine Chibout,Michael Merz,Gerd A. Kullak-Ublick,Gerd A. Kullak-Ublick +6 more
TL;DR: The purpose of this review is to summarize the different facets of bile acids in the context of normal physiology, hereditary defects of biles acid transport and DILI.
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Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage.
TL;DR: FXR agonists may have a therapeutic role in conditions associated with ischemic kidney damage and the subsequent progression of AKI to chronic kidney disease (CKD) by ameliorating glomerulosclerosis and interstitial fibrosis and by suppressing fibrogenic gene expression.