Gerd A. Kullak-Ublick
University of Zurich
256 Papers
1.4K Citations
Gerd A. Kullak-Ublick is an academic researcher from University of Zurich. The author has contributed to research in topics: Medicine & Bile acid. The author has an hindex of 61, co-authored 245 publications. Previous affiliations of Gerd A. Kullak-Ublick include Novartis & National Patient Safety Foundation.
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Papers
The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids
Katrin Popowski,Jyrki J. Eloranta,Michael Saborowski,Michael Fried,Peter J. Meier,Gerd A. Kullak-Ublick +5 more
TL;DR: It is concluded that the hOAT2 gene is critically dependent on HNF-4α and that bile acids repress the h oat2 gene by inhibiting HNF -4α.
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Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor.
TL;DR: It is shown that vitamin D3 transactivates the SLC30A10 gene in a VDR-dependent manner, resulting in increased ZnT10 protein expression, which is critical for zinc and manganese homeostasis.
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Risks of Inflammatory Bowel Disease Treatment with Glucocorticosteroids and Aminosalicylates
TL;DR: Considering the toxicity profile of conventional glucocorticosteroids, one primary goal of treatment in IBD should be corticosteroid-free remission, and therapy with budesonide may result in a better safety profile.
Cost-effectiveness of cadaveric and living-donor liver transplantation.
Markus Sagmeister,Beat Müllhaupt,Zakiyah Kadry,Gerd A. Kullak-Ublick,Pierre A. Clavien,Eberhard L. Renner +5 more
TL;DR: Assessment of the marginal cost-effectiveness of cadaveric and living-donor orthotopic liver transplantation (OLT) in adults with ESLD found that offering living- Donor OLT in addition to cadaVERic OLT improves survival at costs comparable to accepted therapies in medicine.
Sirtuin 5 as a novel target to blunt blood–brain barrier damage induced by cerebral ischemia/reperfusion injury
Candela Diaz-Cañestro,Mario Merlini,Nicole R. Bonetti,Luca Liberale,Luca Liberale,Patricia Wüst,Sylvie Briand-Schumacher,Jan Klohs,S Costantino,Melroy X. Miranda,Gabriele Schoedon-Geiser,Gerd A. Kullak-Ublick,Alexander Akhmedov,Francesco Paneni,Jürg H. Beer,Thomas F. Lüscher,Giovanni G. Camici +16 more
TL;DR: SIRT5 mediates I/R-induced brain damage by increasing BBB permeability through degradation of occludin, mediated by the PI3K/Akt pathway, and is suggested as a novel therapeutic target.
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