Pancreatic diseases in children.

We present a case of a submucosal tumor in the stomach that was suspicious for malignancy on preoperative endosonography The resected tumor was histologically diagnosed as a ductal adenocarcinoma that originated in ectopic pancreatic tissue in the gastric wall Although malignant transformation in ectopic pancreas is extremely rare, it remains an important consideration in the differential diagnosis of gastric submucosal masses

Carcinoma arising from ectopic pancreas in the stomach: Endosonographic detection of malignant change

Heterotopic pancreas in the stomach is a relatively common congenital condition, but the risk of malignant transformation is extremely low. In this study, we describe a case of adenocarcinoma arising from a gastric heterotopic pancreas and we consider its morphological and immunohistochemical features and genetic analysis, in order to examine its histogenesis. This unusual sequela was seen in a 57-year-old woman. Image studies showed a protruding lesion with a central ulcer located in the lesser curvature from the angle to the body of the stomach. A biopsy specimen confirmed this lesion as adenocarcinoma before total gastrectomy. The tumor showed mixed patterns of solid neoplastic-cell proliferation and moderately differentiated glandular structures, and also showed transitional lesions to obvious malignancy, that is, dysplasia, or adenocarcinoma in situ. Neoplastic cells had positive immunoreactivity for carbohydrate antigen (CA) 19-9, mucin (MUC) 1, and insulin, and the mutant allele-specific amplification method revealed a point mutation at K-ras codon 12 (GGT [Gly]-->GAT [Asp]), which is the most common mutational change observed in patients with pancreatic carcinoma. The features of the present case provide clear evidence that this tumor originated from heterotopic pancreatic tissue rather than from gastric epithelium.

Adenocarcinoma arising in gastric heterotopic pancreas: Clinicopathological and immunohistochemical study with genetic analysis of a case

Acinar cell carcinoma arising in the stomach: a case report with literature review.

Pathology of the Pancreas: A Practical Approach

We present a case of ductal adenocarcinoma originating in a heterotopic pancreas in a 60-year-old patient The tumor developed at the esophagogastric junction in a hiatal hernia The nontumoral pancreatic tissue showed ductal cystic dystrophy with enclosed stones, as well as lesions of chronic pancreatitis with metaplastic changes The perigastric lymph nodes and the liver contained metastatic deposits Malignant transformation in an ectopic pancreas is exceptional To our knowledge, this would be the first case occurring in such a location We review the literature on the subject and discuss the theory of the tumors arising in an aberrant pancreas

Ductal adenocarcinoma arising in a heterotopic pancreas situated in a hiatal hernia.

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Ductal adenocarcinoma arising in a heterotopic pancreas situated in a hiatal hernia.