Gerard Grosveld
St. Jude Children's Research Hospital
158 Papers
4.3K Citations
Gerard Grosveld is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Chromosomal translocation & Myeloid leukemia. The author has an hindex of 63, co-authored 155 publications. Previous affiliations of Gerard Grosveld include University of Tennessee Health Science Center & The Catholic University of America.
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Papers
Translocation t(6;9) in acute non-lymphocytic leukaemia results in the formation of a DEK-CAN fusion gene.
Marieke von Lindern,Maarten Fornerod,Nike Soekarman,Sjozef van Baal,Martine Jaegle,Anne Hagemeijer,Dirk Bootsma,Gerard Grosveld +7 more
TL;DR: The occurrence of a SET-CAN fusion gene indicates that CAN may be the relevant oncogene involved in leukaemogenesis, and that activation of CAN can be effectuated through fusion of its 3' part to either DEK or SET.
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Negative Regulation of the RelA/p65 Transactivation Function by the Product of the DEK Proto-oncogene *
Morgan A. Sammons,Shan Shan Wan,Nancy L. Vogel,Edwin J. Mientjes,Gerard Grosveld,Brian P. Ashburner +5 more
TL;DR: ChIP assays showed that DEK associates with the promoters of the NF-κB-regulated cIAP2 and IL-8 genes in untreated cells and dissociates from these promoters upon NF-σκB binding in response to TNFα treatment, providing further evidence thatDEK functions to negatively regulate transcription.
63
The restricted expression pattern of the POU factor Oct-6 during early development of the mouse nervous system
TL;DR: The expression pattern of the Oct-6 gene agrees with a role for theOct-6 protein in the establishment and regional specification of the neuroectoderm in vivo and suggests a mechanism for the regulation of the gene.
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Genetic heterogeneity in tuberous sclerosis.
L.A.J. Janssen,L. A. Sandkuyl,E. C. Merkens,J.A. Maat-Kievit,Julian R. Sampson,P. Fleury,R.C.M. Hennekam,Gerard Grosveld,Dick Lindhout,Dicky J. J. Halley +9 more
TL;DR: An approach combining multipoint linkage analysis and heterogeneity tests that has enabled us to obtain significant evidence for locus heterogeneity after studying a relatively small number of families supports a model with two different loci independently causing the disease.
55
•Journal Article
A novel variant of the bcr-abl fusion product in Philadelphia chromosome-positive acute lymphoblastic leukemia.
D. Soekarman,J van Denderen,L. Hoefsloot,M. Moret,T Meeuwsen,J. Van Baal,Anne Hagemeijer,Gerard Grosveld +7 more
TL;DR: Two patients with Philadelphia chromosome-positive acute lymphoblastic leukemia showed novel variants of the chimeric bcr-abl mRNA, which showed a bCr-abl protein with heightened tyrosine kinase activity in blast cells of both patients: one of the P190 type, the other of theP210 type.
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