Gerald Kleymann
Bayer
38 Papers
124 Citations
Gerald Kleymann is an academic researcher from Bayer. The author has contributed to research in topics: Herpes simplex virus & Primase. The author has an hindex of 9, co-authored 33 publications. Previous affiliations of Gerald Kleymann include Bayer Corporation & Bayer HealthCare Pharmaceuticals.
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Papers
Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.
Veronika Hellwig,Anke Mayer-Bartschmid,Hartwig Müller,Gisela Greif,Gerald Kleymann,Werner Zitzmann,Hans-Volker Tichy,Marc Stadler +7 more
TL;DR: Fermentation of P 0297 in bromide-containing culture media led to a shift in secondary metabolite production and yielded monocillins III and II as major metabolites besides monorden as well as the novel compounds pochonin F (10) and a monocillin II glycoside (11) as minor metabolites.
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Superior Efficacy of Helicase-Primase Inhibitor BAY 57–1293 for Herpes Infection and Latency in the Guinea Pig Model of Human Genital Herpes Disease
Judith Baumeister,Ruediger Fischer,Peter Eckenberg,Kerstin Henninger,Helga Ruebsamen-Waigmann,Gerald Kleymann +5 more
TL;DR: Bay 57-1293, a novel non-nucleosidic inhibitor of herpes simplex virus 1 and 2 (HSV-1 and HSV-2), bovine herpesvirus and pseudorabies virus, was studied in the guinea pig model of genital herpes in comparison with the licensed drug valaciclovir (Valtrex) as discussed by the authors.
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Patent
Thiazolyl urea derivatives and their utilization as antiviral agents
Fischer Rudiger,Gerald Kleymann,Baumeister Judith,Wolfgang Bender,Betz Ulrich,Eckenberg Peter,Gabriele Handke,Martin Hendrix,Udo Schneider,Olaf Weber,Kerstin Henninger,Axel Jensen,Jörg Keldenich +12 more
- 24 Feb 2000
TL;DR: In this paper, the invention relates to thiazolyl urea derivatives of formula (I), to a method for the production thereof, and to their use as medicaments, in particular, as antiviral medicaments.
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Efficacy of a Helicase-Primase Inhibitor in Animal Models of Ocular Herpes Simplex Virus Type 1 Infection
Herbert E. Kaufman,Emily D. Varnell,Bryan M. Gebhardt,Hilary W. Thompson,Ephraim Atwal,Helga Rübsamen-Waigmann,Gerald Kleymann +6 more
TL;DR: Oral BAY 57-1293 may be a substitute for eye drops as an effective treatment for herpetic keratitis and might be useful in treating stromal ker atitis and iritis, as well as preventing recurrences of ocular herpes.
26
Patent
Thiazolyl amide derivatives
Rüdiger Fischer,Gerald Kleymann,Ulrich Betz,Judith Baumeister,Wolfgang Bender,Peter Eckenberg,Gabriele Handke,Martin Hendrix,Kerstin Henninger,Axel Jensen,Jörg Keldenich,Udo Schneider,Olaf Weber +12 more
- 12 Dec 2000
TL;DR: In this article, the present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments; however, it does not relate to the use of these compounds as medicine.
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