Gerald Kleymann
University of Tübingen
29 Papers
450 Citations
Gerald Kleymann is an academic researcher from University of Tübingen. The author has contributed to research in topics: RAR-related orphan receptor & Nuclear receptor. The author has an hindex of 12, co-authored 29 publications. Previous affiliations of Gerald Kleymann include Janssen Pharmaceutica & Max Planck Society.
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Papers
Engineered Fv Fragments as a Tool for the One-Step Purification of Integral Multisubunit Membrane Protein Complexes
TL;DR: An indirect immunoaffinity chromatography method based on engineered Fv fragments, which could be reused under continuous operation for several months and obtained five to 10 mg of membrane protein complexes within five hours.
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Patent
Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor rar-related orphan receptor-gamma (rorgamma, nr1f3) activity and for the treatment of chronic inflammatory and autoimmune diseases
Christoph Steeneck,Olaf Kinzel,Christian Gege,Gerald Kleymann,Thomas Hoffmann +4 more
- 28 Feb 2011
TL;DR: In this paper, the authors provide modulators for the orphan nuclear receptor RORγ and methods for treating rorγ mediated diseases by administrating these novel Rorγ modulators to a human or a mammal in need thereof.
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Human β2-adrenergic receptor produced in stably transformed insect cells is functionally coupled via endogenous GTP-binding protein to adenylyl cyclase
Gerald Kleymann,Fritz Boege,Mathias Hahn,Wolfgang Hampe,Subhash G. Vasudevan,Helmut Reiländer +5 more
TL;DR: Spodoptera frugiperda insect cells (Sf9) containing the stably integrated human beta 2-adrenergic receptor gene under the control of the baculovirus IE1 promoter expressed up to 350,000 human receptors/cell.
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Use of nanogold- and fluorescent-labeled antibody Fv fragments in immunocytochemistry.
Sebastien Ribrioux,Gerald Kleymann,Winfried Haase,Karin Heitmann,Christian Ostermeier,Hartmut Michel +5 more
TL;DR: The directly labeled Fv fragments, half the size of an Fab fragment, are at the molecular level the smallest antibody fragments yet described for visualization of biomolecules in microscopy.
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Patent
PYRROLO CARBOXAMIDES AS MODULATORS OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORy, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES
Christoph Steeneck,Olaf Kinzel,Christian Gege,Gerald Kleymann,Thomas Hoffmann +4 more
- 03 Dec 2012
TL;DR: In this paper, the authors proposed a method for treating ROR mediated diseases by administrating these novel ROR? modulators to a human or a mammal in need of them.
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