Georgios A. Spyroulias
University of Patras
146 Papers
1.1K Citations
Georgios A. Spyroulias is an academic researcher from University of Patras. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 22, co-authored 123 publications. Previous affiliations of Georgios A. Spyroulias include University of Cape Town & University of Florence.
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Papers
Evaluation of the Distribution of Paclitaxel by Immunohistochemistry and Nuclear Magnetic Resonance Spectroscopy After the Application of a Drug-Eluting Balloon in the Porcine Ureter
Despoina Liourdi,Panagiotis Kallidonis,Iason Kyriazis,Athanasios Tsamandas,Dimitrios Karnabatidis,Panagiotis Kitrou,Georgios A. Spyroulias,Ourania N. Kostopoulou,Kostas D. Marousis,Dimitrios L. Kalpaxis,Dimitrios S. Goumenos,Evangelos Liatsikos +11 more
TL;DR: Reduced inflammation was observed in the ureteral wall after the inflation of a paclitaxel-eluting balloon (PEB) in an attempt to elucidate the possibility of clinical application of PEBs in the Ureter.
Comprehensive Fragment Screening of the SARS‐CoV‐2 Proteome Explores Novel Chemical Space for Drug Development
Hannes Berg,Maria Alexandra Wirtz Martin,Nadide Altincekic,Islam Alshamleh,Jasleen Kaur Bains,Julius Blechar,Betül Ceylan,Vanessa de Jesus,Karthikeyan Dhamotharan,Christin Fuks,Santosh Lakshmi Gande,Bruno Hargittay,Katharina F. Hohmann,Marie T Hutchinson,Sophie Marianne Korn,Robin Krishnathas,Felicitas Kutz,Verena Linhard,Tobias Matzel,Nathalie Meiser,Anna Niesteruk,Dennis J. Pyper,Linda Schulte,Sven Trucks,Kamal Azzaoui,Marcel J. J. Blommers,Yojana Gadiya,Reagon Karki,Andrea Zaliani,Philip Gribbon,Marcius S. Almeida,Cristiane D. Anobom,Anna L. Bula,Matthias Buetikofer,Ícaro Putinhon Caruso,Isabella C. Felli,Andrea T. Da Poian,Gisele Cardoso Amorim,Nikolaos K. Fourkiotis,Angelo Gallo,Dhiman Ghosh,Francesco Gomes-Neto,Oksana Gorbatyuk,Bing Hao,Vilius Kurauskas,Lauriane Lecoq,Yunfeng Li,N. C. Mebus-Antunes,Miguel Mompeán,T. C. Neves-Martins,Martí Ninot-Pedrosa,Anderson S. Pinheiro,Letizia Pontoriero,Yulia Pustovalova,Roland Riek,Angus Everett Robertson,Marie Jose Abi Saad,Miguel A. Treviño,Aikaterini C. Tsika,Fabio C. L. Almeida,Ad Bax,Katherine A. Henzler-Wildman,Jeffrey S Hoch,Kristaps Jaudzems,Douglas V. Laurents,Julien Orts,Roberta Pieratelli,Georgios A. Spyroulias,Elke Duchardt-Ferner,Jan Ferner,Boris Fuertig,Martin Hengesbach,Frank Löhr,Nusrat S. Qureshi,Christian Richter,Krishna Saxena,Andreas Schlundt,Sridhar Sreeramulu,Anna Wacker,Julia E. Weigand,Julia Wirmer-Bartoschek,Jens Woehnert,Harald Schwalbe +82 more
TL;DR: This investigation provides novel structural and chemical space for structure‐based drug design against the SCoV2 proteome and identify functional moieties (chemotypes) of the ligands occupying these pockets.
A Peptide Mimetic of 5-Acetylneuraminic Acid-Galactose Binds with High Avidity to Siglecs and NKG2D.
TL;DR: The results support the conclusion that svH1C mimics Neu5Ac-containing sequences and interacts with cell-surface receptors with avidities sufficient to induce biological responses at low concentrations, and the attenuation of inhibitory receptors suggests that the peptide has characteristics of a checkpoint inhibitor.
McIdas localizes at centrioles and controls centriole numbers through PLK4-dependent phosphorylation
Marina Arbi,Margarita Skamnelou,Spyridoula Bournaka,Sihem Zitouni,Stavroula Tsaridou,Ozge Karayel,Catherine G. Vasilopoulou,Aikaterini C. Tsika,Nickolaos Nikiforos Giakoumakis,Georgios A. Spyroulias,Matthias Mann,Mónica Bettencourt-Dias,Stavros Taraviras,Zoi Lygerou +13 more
TL;DR: It is demonstrated that McIdas is present at the middle part of centrioles, where it exhibits a differential localization during the cell cycle, and Mutational analysis shows that Mc Idas phosphorylation is important for centriole number control.
Untargeted 1H-NMR Urine Metabolomic Analysis of Preterm Infants with Neonatal Sepsis
P. Georgiopoulou,Styliani A. Chasapi,Irene Christopoulou,Anastasia Varvarigou,Georgios A. Spyroulias +4 more
TL;DR: Through nuclear magnetic resonance (NMR) based metabolomics, the urine metabolomic profile of septic neonates is investigated and those metabolites which could be indicative for an initial discrimination between the diseased and the healthy ones are revealed.