Georgios A. Spyroulias
University of Patras
146 Papers
1.1K Citations
Georgios A. Spyroulias is an academic researcher from University of Patras. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 22, co-authored 123 publications. Previous affiliations of Georgios A. Spyroulias include University of Cape Town & University of Florence.
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Papers
Peptide inhibitors of angiotensin-I converting enzyme based on angiotensin (1-7) with selectivity for the C-terminal domain.
Rogerio Luiz da Silva,Athanasios Papakyriakou,Adriana K. Carmona,Georgios A. Spyroulias,Edward D. Sturrock,Patrícia Alessandra Bersanetti,Clovis R. Nakaie +6 more
TL;DR: Findings from synthetized 15 derivatives of Ang (1-7), sequentially removing the N-terminal amino acids and modifying peptides extremities, to find molecules with improved selectivity and inhibition properties support ongoing studies using insights from the binding of Ac-Ang (2-7)-NH2 to develop effective cACE inhibitors.
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Structure activity relationship of the binding of p-coumaroyl glucose to glycogen phosphorylase and its effect on hepatic cell metabolic pathways
Anastasia S. Tsagkarakou,Styliani A. Chasapi,Symeon M. Koulas,Ioannis Tsialtas,Efthimios Kyriakis,Christina E. Drakou,Sándor Kun,László Somsák,Georgios A. Spyroulias,Anna-Maria G. Psarra,Demetres D. Leonidas +10 more
- 01 Dec 2021
TL;DR: The binding of p-coumaroyl glucose to glycogen phosphorylase (GP; a pharmaceutical target for the development of antihyperglycaemic drugs) has been studied by kinetics and X-ray crystallography while its effect to HepG2 cells metabolism has been assessed by NMR metabolomics.
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(1)H, (13)C and (15)N backbone and side-chain resonance assignment of the LAM-RRM1 N-terminal module of La protein from Dictyostelium discoideum.
Christos T. Chasapis,Aikaterini I. Argyriou,Maria Apostolidi,Parthena Konstantinidou,Detlef Bentrop,Constantinos Stathopoulos,Georgios A. Spyroulias +6 more
TL;DR: The backbone and side-chain assignments of the 1H, 13C and 15N resonances of the 191-residue LAM–RRM1 region of the La protein from the lower eukaryote Dictyostelium discoideum are presented and its secondary structure prediction is presented.
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Unveiling the Essential Role of Arkadia’s Non-RING Elements in the Ubiquitination Process
Maria Birkou,Georgia N. Delegkou,Konstantinos D. Marousis,Nefeli Fragkaki,Tamara Toro,Vasso Episkopou,Georgios A. Spyroulias +6 more
TL;DR: The results support that the non-RING elements including the NRGA and TIER motifs are required for E2-E3 recognition and interaction and for efficient auto-ubiquitination and showed that Arkadia isoform-1 does not interact with free ubiquitin.