Georges Abboud
University of Florida
27 Papers
121 Citations
Georges Abboud is an academic researcher from University of Florida. The author has contributed to research in topics: Cytotoxic T cell & Biology. The author has an hindex of 12, co-authored 19 publications.
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Papers
Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity
Bram Slütter,Bram Slütter,Natalija Van Braeckel-Budimir,Georges Abboud,Steven M. Varga,Shahram Salek-Ardakani,John T. Harty +6 more
TL;DR: Time-dependent changes in expression of genes critical for lymphocyte trafficking and TRM differentiation, in concert with enrichment of TCM, diminish the capacity of circulating memory CD8 T cells to form TRM with time, explaining why IAV-induced TRM are not stably maintained.
Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells.
Seung-Chul Choi,Anton A. Titov,Georges Abboud,Howard R. Seay,Todd M. Brusko,Derry C. Roopenian,Shahram Salek-Ardakani,Laurence Morel +7 more
TL;DR: It is shown that inhibiting glucose metabolism results in a drastic reduction of the frequency and number of TFH cells in lupus-prone mice, and blocking glucose metabolism may provide an effective therapeutic approach to treat systemic autoimmunity by eliminating autoreactiveTFH cells while preserving protective immunity against pathogens.
Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis.
Georges Abboud,Seung-Chul Choi,Nathalie Kanda,Leilani Zeumer-Spataro,Derry C. Roopenian,Laurence Morel +5 more
TL;DR: It is proposed that K/BxN mice are another model in which autoreactive Tfh cells are highly glycolytic and that their function can be limited by inhibiting glucose metabolism.
Natural Killer Cells and Innate Interferon Gamma Participate in the Host Defense against Respiratory Vaccinia Virus Infection.
Georges Abboud,Vikas Tahiliani,Pritesh Desai,Kyle Varkoly,John P. Driver,Tarun E. Hutchinson,Shahram Salek-Ardakani +6 more
TL;DR: It is demonstrated that NK cells are recruited, activated, and contribute to protection of the lung during a severe respiratory infection with vaccinia virus, and an innate immune role for NK cell-derived IFN-γ is demonstrated.
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CD8 T Cells Use IFN-γ To Protect against the Lethal Effects of a Respiratory Poxvirus Infection
John Goulding,Georges Abboud,Vikas Tahiliani,Pritesh Desai,Tarun E. Hutchinson,Shahram Salek-Ardakani +5 more
TL;DR: Transfer experiments indicated that CD8 T cell–autonomous expression of IFN-γ restricts virus-induced lung pathology and dissemination to visceral tissues and is necessary for clearance of virus.
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