George M. Church
Harvard University
964 Papers
10K Citations
George M. Church is an academic researcher from Harvard University. The author has contributed to research in topics: Biology & Genome. The author has an hindex of 172, co-authored 900 publications. Previous affiliations of George M. Church include University of Utah & Duke University.
Chat about Author
Papers
Efficient Reassignment of a Frequent Serine Codon in Wild-Type Escherichia coli.
Joanne M. L. Ho,Noah M. Reynolds,Keith Rivera,Morgan P Connolly,Li-Tao Guo,Jiqiang Ling,Darryl J. Pappin,George M. Church,Dieter Söll +8 more
TL;DR: The results indicate that the 3-iodo-l-phenylalanyl-tRNA synthetase (IFRS)/tRNA(Pyl) pair can efficiently outcompete the cellular machinery to reassign select sense codons in wild-type E. coli.
Patent
Multiplex decoding of sequence tags in barcodes
George M. Church,Jay Shendure,Gregory J. Porreca,Nikos Reppas +3 more
- 06 Feb 2008
48
A Survey of Genomic Traces Reveals a Common Sequencing Error, RNA Editing, and DNA Editing
Alexander Wait Zaranek,Erez Y. Levanon,Erez Y. Levanon,Tomer Zecharia,Tom Clegg,George M. Church +5 more
TL;DR: It is shown that the NCBI Trace Archive provides a valuable resource for the investigation of the phenomena of DNA and RNA editing, as well as setting the stage for a comprehensive mapping of editing events in large-scale genomic datasets.
Patent
Large gene excision and insertion
Susan M. Byrne,George M. Church +1 more
- 19 Nov 2014
TL;DR: In this paper, the authors described methods of simultaneously excising large nucleic acid sequences from a target nucleic acids and inserting large foreign nucleic sequences into the target NCA sequence using DNA binding protein nucleases.
47
To help aging populations, classify organismal senescence.
Stuart R. G. Calimport,Barry Bentley,Claire E. Stewart,Graham Pawelec,Angelo Scuteri,Manlio Vinciguerra,Cathy Slack,Danica Chen,Lorna W. Harries,Gary Marchant,G. Alexander Fleming,Michael J. Conboy,Adam Antebi,Gary W. Small,Jesús Gil,Edward G. Lakatta,Arlan Richardson,Clifford J. Rosen,Karoly Nikolich,Tony Wyss-Coray,Lawrence Steinman,Thomas J. Montine,João Pedro de Magalhães,Judith Campisi,George M. Church +24 more
TL;DR: A systematic and comprehensive approach to the classification and staging of organismal senescence and aging-related diseases at the organ and tissue levels is described in order to guide policy and practice and enable appropriate interventions and clinical guidance, systems, resources, and infrastructure.