George Caputa
Max Planck Society
14 Papers
1 Citations
George Caputa is an academic researcher from Max Planck Society. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 5, co-authored 7 publications.
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Papers
Mitochondrial Priming by CD28
Ramon I. Klein Geltink,David O’Sullivan,Mauro Corrado,Anna Bremser,Michael D. Buck,Joerg M. Buescher,Elke Firat,Xuekai Zhu,Gabriele Niedermann,George Caputa,Beth Kelly,Ursula Warthorst,Anne Rensing-Ehl,Ryan Kyle,Lana Vandersarren,Jonathan D. Curtis,Annette E. Patterson,Simon J. Lawless,Katarzyna M. Grzes,Jing Qiu,David E. Sanin,Oliver Kretz,Oliver Kretz,Tobias B. Huber,Tobias B. Huber,Sophie Janssens,Bart N. Lambrecht,Angelika S. Rambold,Edward J. Pearce,Erika L. Pearce +29 more
TL;DR: Early CD28-dependent mitochondrial engagement is needed for T cells to remodel cristae, develop SRC, and rapidly produce cytokines upon restimulation-cardinal features of protective memory T-cells.
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Triacylglycerol synthesis enhances macrophage inflammatory function
Angela Castoldi,Lauar B. Monteiro,Lauar B. Monteiro,Nikki van Teijlingen Bakker,Nikki van Teijlingen Bakker,David E. Sanin,Nisha Rana,Mauro Corrado,Alanna M. Cameron,Fabian Hässler,Mai Matsushita,George Caputa,Ramon I. Klein Geltink,Jörg Büscher,Joy Edwards-Hicks,Erika L. Pearce,Edward J. Pearce,Edward J. Pearce +17 more
TL;DR: The authors show that this triglyceride synthesis is requisite for prostaglandin E2 production and subsequent inflammatory activation, and place LDs in a position of central importance in inflammatory macrophage activation.
Triacylglycerol synthesis enhances macrophage inflammatory function
Angela Castoldi,Lauar B. Monteiro,Nikki van Teijlingen Bakker,Nikki van Teijlingen Bakker,David E. Sanin,Nisha Rana,Mauro Corrado,Alanna M. Cameron,Fabian Hässler,Mai Matsushita,George Caputa,Ramon I. Klein Geltink,Jörg Büscher,Joy Edwards-Hicks,Erika L. Pearce,Edward J. Pearce,Edward J. Pearce +16 more
TL;DR: It is shown that macrophages stimulated with lipopolysaccharide plus interferon-γ (IFNγ) accumulate TGs in LDs, and long-chain acylcarnitine levels, placing LDs in a position of central functional importance in inflammatory macrophage function.
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A common framework of monocyte-derived macrophage activation
David E. Sanin,Yan-Xin Ge,Emilija Marinkovic,Agnieszka M. Kabat,Angela Castoldi,George Caputa,Katarzyna M. Grzes,Jonathan D. Curtis,Elizabeth D. Thompson,Sebastian Willenborg,Stefanie Dichtl,Susanne Reinhardt,Andreas Dahl,Erika L. Pearce,Sabine A. Eming,Alexander Gerbaulet,A Roers,Peter J. Murray,Edward J. Pearce +18 more
TL;DR: Sanin et al. as mentioned in this paper developed a framework for classifying macrophage activation states across different tissues and stimuli using single-cell transcriptomics, and verified this model with adoptive cell transfer experiments and identified transient RELMα expression as a feature of monocyte-derived macrophages.
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An LKB1–mitochondria axis controls TH17 effector function
Francesc Baixauli,Klara Piletič,Daniel J. Puleston,Matteo Villa,Cameron S. Field,Lea J. Flachsmann,Andrea Quintana,Nisha Rana,Joy Edwards-Hicks,Mai Matsushita,Michal A. Stanczak,Katarzyna M. Grzes,Agnieszka M. Kabat,Mario Fabri,George Caputa,Beth Kelly,Mauro Corrado,Yaarub Musa,Katarzyna J. Duda,Gerhard Mittler,David O’Sullivan,Hiromi Sesaki,Thomas Jenuwein,Joerg Martin Buescher,Edward J. Pearce,David E. Sanin,Erika L. Pearce +26 more
TL;DR: In this paper , a multi-omics approach revealed that the serine/threonine kinase liver-associated kinase B1 (LKB1) couples mitochondrial function to cytokine expression in T helper 17 (TH17) cells by regulating TCA cycle metabolism and transcriptional remodeling.
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