George A. Tanner
Indiana University
36 Papers
593 Citations
George A. Tanner is an academic researcher from Indiana University. The author has contributed to research in topics: Polycystic kidney disease & Autosomal dominant polycystic kidney disease. The author has an hindex of 21, co-authored 36 publications.
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Papers
Uropathogenic Escherichia coli P and Type 1 fimbriae act in synergy in a living host to facilitate renal colonization leading to nephron obstruction.
Keira Melican,Ruben M. Sandoval,Abdul Kader,Lina Josefsson,George A. Tanner,Bruce A. Molitoris,Agneta Richter-Dahlfors +6 more
TL;DR: The results reveal the importance of physiological factors such as filtration in determining bacterial colonization patterns, and demonstrate that the spatial resolution of an infectious niche can be as small as the center, or periphery, of a tubule lumen.
Effects of renal artery occlusion on kidney function in the rat.
TL;DR: Kidney function after restoration of blood flow was studied using clearance and micropuncture techniques, and renal insufficiency appears to be primarily due to tubular leakiness and obstruction.
125
Bacterial infection-mediated mucosal signalling induces local renal ischaemia as a defence against sepsis
Keira Melican,Jorrit Boekel,Lisa E. Månsson,Ruben M. Sandoval,George A. Tanner,Örjan Källskog,Fredrik Palm,Fredrik Palm,Bruce A. Molitoris,Agneta Richter-Dahlfors +9 more
TL;DR: A previously undescribed innate vascular response to mucosal infection, allowing isolation and eradication of the pathogen, may be relevant in antibiotics delivery in pyelonephritis patients and the use of anticoagulants in sepsis.
115
Real-time studies of the progression of bacterial infections and immediate tissue responses in live animals.
Lisa E. Månsson,Keira Melican,Jorrit Boekel,Ruben M. Sandoval,Isabelle Hautefort,George A. Tanner,Bruce A. Molitoris,Agneta Richter-Dahlfors +7 more
TL;DR: By combining intravital multiphoton microscopy and bacterial genetics, a technique enabling real‐time imaging of bacterial proliferation and tissue responses in a live animal is developed, revealing the subtle and temporal roles of bacterial virulence factors in vivo.
92
Two-photon microscopy: Visualization of kidney dynamics
TL;DR: To accomplish expression of specific proteins in vivo, cDNAs of fluorescently labeled proteins have been cloned into adenovirus vectors and infused by micropuncture to induce proximal tubule cell infection and protein expression.
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