Gentzane Sánchez-Elexpuru
Autonomous University of Madrid
5 Papers
Gentzane Sánchez-Elexpuru is an academic researcher from Autonomous University of Madrid. The author has contributed to research in topics: Medicine & Zebrafish. The author has an hindex of 2, co-authored 2 publications.
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Papers
Toward the use of novel alternative methods in epilepsy modeling and drug discovery
Claudia Miguel Sanz,Miriam Martinez Navarro,Daniela Constanza Caballero Díaz,Gentzane Sánchez-Elexpuru,Vincenzo Di Donato +4 more
TL;DR: An overview of the state of art in epilepsy modeling describing gold standard animal models used up to date and the possible alternatives for this research field is presented, mainly on ex vivo, in vitro, and in vivo larval zebrafish models contributing to the 3R in epilepsy modeled and drug screening.
4
An inducible expression system for the manipulation of autophagic flux in vivo
Lars Schlotawa,Ana Lopez,Gentzane Sánchez-Elexpuru,Sylwia D. Tyrkalska,David C. Rubinsztein,Angeleen Fleming +5 more
TL;DR: In this paper , an inducible expression system to up- or down-regulate autophagy in vivo, in zebrafish, was developed and validated using Lc3-II blots and puncta analysis.
2
Enhanced sensitivity of laforin- and malin-deficient mice to the convulsant agent pentylenetetrazole.
TL;DR: Epm2a−/− and Epm2b−-/− mice present an increased sensitivity to the convulsant agent PTZ that may reflect different degrees of increased GABAA receptor-mediated hyperexcitability.
Unexpected Phenotype Reversion and Survival in a Zebrafish Model of Multiple Sulfatase Deficiency
Angeleen Fleming,Low Zhe Xuan,Gentzane Sánchez-Elexpuru,Sarah Williams,Dylan Windell,Michael H. Gelb,Zackary M. Herbst,Lars Schlotawa,David C. Rubinsztein +8 more
TL;DR: The characterisation of a sumf1 null zebrafish model successfully recapitulates the pathology of MSD such as cranial malformation, altered bone development, an enlarged population of microglia, and growth retardation during early development but lacks early lethality of mouse Sumf1 −/− models.
Tau-Induced Pathology in Epilepsy and Dementia: Notions from Patients and Animal Models.
Marina P. Sánchez,Ana M. Garcia-Cabrero,Ana M. Garcia-Cabrero,Gentzane Sánchez-Elexpuru,Daniel F Burgos,José M. Serratosa +5 more
TL;DR: The diagnosis of dementia and epilepsy in early stages of those diseases may be helpful for the initiation of treatments that could prevent the generation of epileptic activity and cognitive deterioration.