Genomics Study Syndicate
University of Manchester
4 Papers
16 Citations
Genomics Study Syndicate is an academic researcher from University of Manchester. The author has contributed to research in topics: Single-nucleotide polymorphism & Rheumatoid arthritis. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Genomics Study Syndicate include University of Virginia.
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Papers
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
Steve Eyre,John Bowes,John Bowes,Dorothée Diogo,Dorothée Diogo,Annette Lee,Anne Barton,Anne Barton,Paul Martin,Paul Martin,Alexandra Zhernakova,Alexandra Zhernakova,Eli A. Stahl,Eli A. Stahl,Sebastien Viatte,Sebastien Viatte,Kate McAllister,Kate McAllister,Christopher I. Amos,Leonid Padyukov,René E. M. Toes,Tom W J Huizinga,Cisca Wijmenga,Gosia Trynka,Lude Franke,Harm-Jan Westra,Lars Alfredsson,Xinli Hu,Cynthia Sandor,Cynthia Sandor,Paul I.W. de Bakker,Sonia Davila,Chiea Chuen Khor,Khai Koon Heng,Robert Andrews,Sarah Edkins,Sarah E. Hunt,Cordelia Langford,Deborah P M Symmons,Deborah P M Symmons,Genomics Study Syndicate,Patrick Concannon,Suna Onengut-Gumuscu,Stephen S. Rich,Panos Deloukas,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Lisbeth Ärlsetig,Javier Martin,Solbritt Rantapää-Dahlqvist,Robert M. Plenge,Robert M. Plenge,Soumya Raychaudhuri,Lars Klareskog,Peter K. Gregersen,Jane Worthington,Jane Worthington +56 more
TL;DR: This study illustrates the advantages of dense SNP mapping analysis to inform subsequent functional investigations and refined the peak of association to a single gene for 19 loci, identified secondary independent effects at 6 loci and identified association to low-frequency variants at 4 loci.
Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis
Batool Hassan,James R Maxwell,Kimme L. Hyrich,Genomics Study Syndicate,Anne Barton,Jane Worthington,John D. Isaacs,Ann W. Morgan,Anthony G. Wilson +8 more
TL;DR: This study shows that genotype at the functional sIL-6R A358C SNP is not associated with response to anti-TNF treatment in patients with RA.
Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: a Mendelian randomisation approach
Annie Yarwood,Sebastien Viatte,Darren Plant,Ann W. Morgan,Ann W. Morgan,John D. Isaacs,Anthony G. Wilson,Kimme L. Hyrich,Steve Eyre,Anne Barton,Anne Barton,Genomics Study Syndicate +11 more
TL;DR: Investigation of the effect of vitamin D on response to anti-TNF therapy in RA patients from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS) cohort, which includes patients recruited across the UK.
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