Gengsheng Chen
Washington University in St. Louis
21 Papers
3 Citations
Gengsheng Chen is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 1, co-authored 4 publications.
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Papers
Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease
Muhammad Ali,D. Archer,Priyanka Gorijala,Daniel Western,Jigyasha Timsina,Maria Victoria Fernandez,Claudia L. Satizabal,Qiong Yang,Alexa S. Beiser,Ruiqi Wang,Gengsheng Chen,Brian A. Gordon,Tammie L.S. Benzinger,Chengjie Xiong,John C. Morris,Randall J. Bateman,Celeste M. Karch,Eric McDade,Alison Goate,Sudha Seshadri,Richard Mayeux,Reisa A. Sperling,Rachel F. Buckley,Keith A. Johnson,Hong-Hee Won,Sang Hyuk Jung,Hang-Rai Kim,Sang Won Seo,Hee Jin Kim,Elizabeth C. Mormino,Simon M. Laws,Kang-Hsien Fan,M. Ilyas Kamboh,Prashanthi Vemuri,Vijay K. Ramanan,Hyun-Sik Yang,Allen Wenzel,Hema Sekhar Reddy Rajula,Aniket Mishra,Carole Dufouil,Stéphanie Debette,Oscar L. Lopez,Steven T. DeKosky,Michael W. Nagle,Timothy J. Hohman,Yun Ju Sung,Logan Dumitrescu,Carlos Cruchaga +47 more
TL;DR: The authors performed a genome-wide association study on the largest collection of amyloid imaging data (N = 13,409) to date, across multiple ethnicities from multicenter cohorts to identify variants associated with Alzheimer's disease (AD) risk.
22
Investigating White Matter Neuroinflammation in Alzheimer Disease Using Diffusion-Based Neuroinflammation Imaging.
Qing Wang,Suzanne E. Schindler,Gengsheng Chen,Nicole S. McKay,Austin A. McCullough,Shaney Flores,Jingxia Liu,Zhexian Sun,Sicheng Wang,Wenshang Wang,Jason Hassenstab,Carlos Cruchaga,R. Perrino,Anne M. Fagan,John C Morris,Yong Wang,Tammie L.S. Benzinger +16 more
TL;DR: It is found that cognitively normal individuals with positive CSF Aβ42/Aβ40 and p-tau181 had higher HR than healthy controls and those with positive CSF Aβ42/Aβ40 but negative p-tau181 but negative p-tau181 were found in individuals with positive CSF Aβ42/Aβ40.
15
Baseline Microglial Activation Correlates With Brain Amyloidosis and Longitudinal Cognitive Decline in Alzheimer Disease
Qiang Wang,Gengsheng Chen,Suzanne E. Schindler,Jon Christensen,Nicole S. McKay,Mingxian Liu,Sicheng Wang,Zhexian Sun,Jason Hassenstab,Yi Su,Shaney Flores,Russ C. Hornbeck,Lisa Cash,Carlos Cruchaga,Anne M. Fagan,Zhude Tu,John C. Morris,Mark A. Mintun,Yong Wang,Tammie L.S. Benzinger +19 more
- 08 Mar 2022
TL;DR: This study provides Class II evidence that in patients with AD, higher baseline [11C]PK11195 SUVR averaged in the whole cortical regions was associated with longitudinal decline on cognitive tests.
14
Intracranial internal carotid artery calcification is not predictive of future cognitive decline
Farzaneh Rahmani,Marina Nguyen,Charles Chen,Nicole S. McKay,Aylin Dincer,Nelly Joseph-Mathurin,Gengsheng Chen,Jingxia Liu,Hilary L.P. Orlowski,John C. Morris,Tammie L.S. Benzinger +10 more
TL;DR: The predictive value of ICAC (ICAC) for future risk of cognitive decline and compared the results with conventional imaging biomarkers of dementia was evaluated in a retrospective observational cohort of 230 participants with a PET-CT scan within 18 months of a baseline clinical assessment and longitudinal imaging assessments as discussed by the authors .
8
Intracranial Internal Carotid Artery Calcification Is Not Predictive of Future Cognitive Decline
Farzaneh Rahmani,Marina Nguyen,Charles D. Chen,Nicole S. McKay,Aylin Dincer,Nelly Joseph-Mathurin,Gengsheng Chen,Jingxia Liu,Hilary L. P. Orlowski,John C. Morris,Tammie L.S. Benzinger +10 more
- 22 Sep 2021
TL;DR: In elderly and preclinical AD populations, atherosclerosis of large intracranial vessels as demonstrated through ICA calcification is not directly associated with a future risk of dementia, cognitive impairment, or progression of imaging biomarkers of AD or small vessel disease.