Genevieve Jacobs
National Institutes of Health
4 Papers
Genevieve Jacobs is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 4, co-authored 4 publications.
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Papers
Image-guided drug delivery with magnetic resonance guided high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model.
Ashish Ranjan,Genevieve Jacobs,David L. Woods,Ayele H. Negussie,Ari Partanen,Ari Partanen,Ari Partanen,Pavel S. Yarmolenko,Pavel S. Yarmolenko,C. Gacchina,Karun Sharma,Victor Frenkel,Bradford J. Wood,Matthew R. Dreher +13 more
TL;DR: Doxorubicin bio-distribution in non-tumor organs/tissues was fairly similar between treatment groups, suggesting this technique has potential for clinical translation as an image-guided method to deliver drug to a solid tumor.
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Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound.
Ayele H. Negussie,Pavel S. Yarmolenko,Ari Partanen,Ashish Ranjan,Genevieve Jacobs,David L. Woods,Henry Bryant,David Thomasson,Mark W. Dewhirst,Bradford J. Wood,Matthew R. Dreher +10 more
TL;DR: Stability, imageability, and MR-HIFU monitoring and control of content release suggest that MR-Doxorubicin and Gd-HP-DO3A combined with iLTSL may enable real-time monitoring and spatial control ofcontent release.
Mild hyperthermia with magnetic resonance-guided high-intensity focused ultrasound for applications in drug delivery
Ari Partanen,Pavel S. Yarmolenko,Antti Viitala,Sunil Appanaboyina,Dieter Haemmerich,Ashish Ranjan,Genevieve Jacobs,David L. Woods,Julia Enholm,Bradford J. Wood,Matthew R. Dreher +10 more
TL;DR: An MR-HIFU mild hyperthermia heating algorithm was developed, resulting in accurate and homogeneous heating within the targeted region in vitro and in vivo, which is suitable for applications in drug delivery.
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Direct Quantification and Comparison of Intratumoral Hypoxia following Transcatheter Arterial Embolization of VX2 Liver Tumors with Different Diameter Microspheres
Elliot Levy,Carmen Gacchina Johnson,Genevieve Jacobs,David L. Woods,Karun Sharma,Karun Sharma,John Bacher,Andrew L. Lewis,Matthew R. Dreher,Bradford J. Wood +9 more
TL;DR: In the rabbit VX2 liver tumor model, three tested microsphere diameters failed to cause tumor hypoxia as measured by a fiberoptic probe sensor according to the adopted Hypoxia definitions.
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