Gen Muto
Tohoku University
12 Papers
181 Citations
Gen Muto is an academic researcher from Tohoku University. The author has contributed to research in topics: Diabetes mellitus & Streptozotocin. The author has an hindex of 8, co-authored 12 publications.
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Papers
Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with N-acetylcysteine.
Mikio Sagara,Jo Satoh,Ryuichi Wada,Soroku Yagihashi,Ken Ichi Takahashi,Masamitsu Fukuzawa,Gen Muto,Yoshiko Muto,Takayoshi Toyota +8 more
TL;DR: N-acetylcysteine inhibited the development of functional and structural abnormalities of the peripheral nerve in streptozotocin-induced diabetic rats.
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Angiotensin converting enzyme inhibitors suppress production of tumor necrosis factor-α in vitro and in vivo
Masamitsu Fukuzawa,Jo Satoh,Mikio Sagara,Gen Muto,Yoshiko Muto,Sachiko Nishimura,Shuichi Miyaguchi,Xiao Ling Qiang,Yoshiyuki Sakata,Tetsuya Nakazawa,Fumiko Ikehata,Setsu Ohta,Takayoshi Toyota +12 more
TL;DR: Results indicate that ACE inhibitors such as captopril, delapril and cilazapril have an inhibitory effect on TNF-α production not only in vitro as previously reported, but also in vivo, although relatively high concentrations and large doses were required in this study.
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Inhibitory effect of troglitazone on diabetic neuropathy in streptozotocin-induced diabetic rats
Xiaoling Qiang,Jo Satoh,Mikio Sagara,Masamitsu Fukuzawa,Takayuki Masuda,Yoshiyuki Sakata,Gen Muto,Yoshiko Muto,Ken Ichi Takahashi,Takayoshi Toyota +9 more
TL;DR: Troglitazone has a beneficial effect on peripheral neuropathy in STZ-induced diabetic rats irrespective of blood glucose concentrations, and is shown to be a free-radical scavenger and a TNF-α inhibitor.
Inhibitory effect of nicotinamide on in vitro and in vivo production of tumor necrosis factor-α
Masamitsu Fukuzawa,Jo Satoh,Gen Muto,Yoshiko Muto,Sachiko Nishimura,Shuichi Miyaguchi,Xiao Ling Qiang,Takayoshi Toyota +7 more
TL;DR: Oral administration of nicotinamide significantly inhibited LPS-induced serum TNF-alpha production measured by ELISA and bioassay in Balb/c mice, indicating an inhibitory effect on TNF -alpha production that may be beneficial to T NF-alpha-mediated diseases.
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Inhibition with N-Acetylcysteine of Enhanced Production of Tumor Necrosis Factor in Streptozotocin-Induced Diabetic Rats
Mikio Sagara,Jo Satoh,Xiao Ping Zhu,Kazuma Takahashi,Masamitsu Fukuzawa,Gen Muto,Yoshiko Muto,Takayoshi Toyota +7 more
TL;DR: Results show that N-acetylcysteine administration significantly suppressed the enhanced TNF production in diabetic rats and indicate that NAC might be useful in preventing TNF-mediated pathological conditions in diabetes.
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