5 Papers
Gen Li is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Spiral ganglion & Hair cell. The author has an hindex of 5, co-authored 5 publications.
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Papers
Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing.
He Zhang,Hong Pan,Hong Pan,Changyang Zhou,Yu Wei,Wenqin Ying,Shuting Li,Guangqin Wang,Chao Li,Yifei Ren,Gen Li,Xu Ding,Yidi Sun,Yidi Sun,Geng Lin Li,Lei Song,Yixue Li,Hui Yang,Zhiyong Liu +18 more
TL;DR: It is believed that CRISPR-stop is a powerful method that will pave the way for high-throughput screening of mouse developmental and functional genes, matching the efficiency of methods available for model organisms such as Drosophila.
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Characterizing a novel vGlut3-P2A-iCreER knockin mouse strain in cochlea
TL;DR: vGlut3‐P2A‐iCreER is an efficient genetic tool to specifically target IHCs for gene manipulation, which is complimentary to Prestin‐CreER strain exclusively labelling cochlear outer hair cells (OHCs).
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Hearing consequences in Gjb2 knock-in mice: implications for human p.V37I mutation.
Xin Lin,Gen Li,Yu Zhang,Jingjing Zhao,Jiawen Lu,Yunge Gao,Huihui Liu,Geng-Lin Li,Tao Yang,Lei Song,Hao Wu +10 more
- 27 Sep 2019
TL;DR: It is concluded that this Gjb2 mutation-induced hearing loss results from 1) reduced cochlear amplifier caused by lowered EP, 2) IHCs excitotoxicity associated with potassium accumulation around hair cells, and 3) progression induced by environmental insults.
Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss.
Jingjing Zhao,Gen Li,Xuan Zhao,Xin Lin,Yunge Gao,Nuno Raimundo,Geng Lin Li,Wei Shang,Hao Wu,Lei Song +9 more
- 02 Apr 2020
TL;DR: The effects of AMPK downregulation on pro-survival function and reduction of oxidative stress indicate AMPK serves as a target to rescue or relieve mitochondrial hearing loss.
Cellular Differences in the Cochlea of CBA and B6 Mice May Underlie Their Difference in Susceptibility to Hearing Loss.
TL;DR: Excessive exocytosis from IHCs in B6 mice may raise the probability of glutamate toxicity in ribbon synapses, which could accumulate over time and eventually lead to early onset hearing loss.