Gen Chen
University of South China
6 Papers
14 Citations
Gen Chen is an academic researcher from University of South China. The author has contributed to research in topics: Mesenteric arteries & Endothelin receptor. The author has an hindex of 2, co-authored 6 publications. Previous affiliations of Gen Chen include Xiangnan University.
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Papers
Minimally Modified LDL-Induced Impairment of Endothelium-Dependent Relaxation in Small Mesenteric Arteries of Mice.
TL;DR: The results showed that mmLDL significantly impaired the acetylcholine-induced endothelium-dependent relaxation of mouse mesenteric arteries with markedly reduced pIC50 and Rmax values, and increases superoxide and nitrotyrosine levels, and damages endothelial microstructure with decreased KCa3.1 and KCa2.3 expression.
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Toll-like receptor protein 4 monoclonal antibody inhibits mmLDL-induced endothelium-dependent vasodilation dysfunction of mouse mesenteric arteries
TL;DR: Investigation of the effect of a Toll-like receptor 4 monoclonal antibody (TLR4 mAb) on mmLDL-induced endothelium-dependent vasodilation (EDV) impairment in mouse mesenteric arteries concluded that regulation of the TLR4 pathway, as well as its downstream NF-κB p65 and p38 MAPK pathways, may be an effective strategy for the prevention and treatment of cardiovascular diseases.
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The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ETA Receptor in Mouse Mesenteric Arteries.
Xi Xie,Chen Chen,Cang-Bao Xu,Jie Lin,Lei Cao,Gen Chen,Jie Li +6 more
- 01 Apr 2020
TL;DR: Minimally modified low-density lipoprotein activates autophagy via the Class III PI3K/Beclin-1 pathway and upregulates the ETA receptor via the downstream NF-κB pathway and was significantly inhibited by 3-MA.
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•Journal Article
[Minimally modified LDL induced impairment of endothelium-dependent relaxation in mesenteric arteries of mice].
TL;DR: Endothelium-dependent relaxation was decreased in a time-dependent and dose-dependent manner by using mmLDL, compared with normal arteries, which induced the impairment of the ultramicrostructure of mesenteric vascular endothelium cell as well as the endot Helium- dependent relaxation.
1
Minimally modified low-density lipoprotein upregulates mouse mesenteric arterial 5-HT1B receptor in vivo via activation of the JAK2/STAT3 pathway
TL;DR: In this article, minimally modified low-density lipoprotein (mmLDL) upregulates mesenteric arterial 5-hydroxytryptamine 1B (5-HT1B) receptor expression by activating the JAK2/STAT3 signaling pathway.