Geert Steurs
Catholic University of Leuven
5 Papers
Geert Steurs is an academic researcher from Catholic University of Leuven. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
Polyketide Synthase-Mediated O-Methyloxime Formation in the Biosynthesis of the Oximidine Anti-cancer Agents.
Dries De Ruysscher,Angus N M Weir,Sofie Dekimpe,Geert Steurs,Ahmed El shemy,Leentje Persoons,Christopher B. Williams,Dirk Daelemans,Matthew P. Crump,Arnout Voet,Wim M. De Borggraeve,Eveline Lescrinier,Joleen Masschelein +12 more
TL;DR: In this article , the authors used a combination of in vivo, in vitro and computational approaches to identify the oximidine gene cluster in Pseudomonas baetica and the characterization of four novel oxIMidine variants, including a structurally simpler intermediate.
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Carbonylation Chemistry Applied to the Synthesis of Benzimidazo[2,1‐ b ]quinazolin‐12‐ones
Sarah Vangrunderbeeck,Tim Balcaen,Cedrick Veryser,Geert Steurs,Wim M. De Borggraeve +4 more
TL;DR: A carbonylative route towards the synthesis of benzimidazo[2,1-b]quinazolin-12-ones was developed in this paper , where the key step consists of an intramolecular carbONYlative lactam formation, starting from N-(2-bromophenyl)-1H-benzimidazol-2-amines.
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Does Supramolecular Gelation Require an External Trigger?
Ruben Van Lommel,Julie Van Hooste,Johannes Vandaele,Geert Steurs,Tom Van der Donck,Frank De Proft,Susana Rocha,Dimitrios Sakellariou,Mercedes Alonso,Wim M. De Borggraeve +9 more
TL;DR: In this paper , a small urea-based molecule spontaneously forms a stable hydrogel by simple mixing without the addition of an external trigger, and the mechanism of the heat-triggered supramolecular gelation was elucidated by a combination of molecular dynamics simulations and quantitative NMR experiments.
From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin
Daniëlle Copmans,Sara Kildgaard,E. Roux,Michèle Partoens,Geert Steurs,Xinhui Wang,Wim M. De Borggraeve,Camila V. Esguerra,Alexander D. Crawford,Thomas Ostenfeld Larsen,Peter de Witte +10 more
TL;DR: The discovery of two new antiseizure compounds, the 2,5-diketopiperazine halimide and its semi-synthetic analogue, plinabulin, and the investigation of two functional analogues, colchicine and indibulin, suggests that microtubule depolymerization does not underpin pl inabulin’s antISEizure action.
Inter-industry R&D spillovers: What difference do they make?
TL;DR: In this article, the impact of intra-and inter-industry R&D spillovers on the level of strategic investments, output, profits, and total welfare when firms compete in both the research and output stages is analyzed.