Gavin Young
University of Oxford
22 Papers
21 Citations
Gavin Young is an academic researcher from University of Oxford. The author has contributed to research in topics: Myosin & Cytoskeleton. The author has an hindex of 7, co-authored 17 publications.
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Papers
Quantitative mass imaging of single biological macromolecules
Gavin Young,Nikolas Hundt,Daniel Cole,Adam Fineberg,Joanna Andrecka,Andrew Tyler,Anna Olerinyova,A Ansari,Erik G. Marklund,Miranda P. Collier,Shane A. Chandler,Olga Tkachenko,Joel D. Allen,Max Crispin,Neil Billington,Yasuharu Takagi,James R. Sellers,Cédric Eichmann,Philipp Selenko,Lukas Frey,Roland Riek,Roland Riek,Martin R. Galpin,Weston B. Struwe,Justin L. P. Benesch,Philipp Kukura +25 more
TL;DR: Interferometric scattering mass spectrometry allows spatiotemporally resolved measurement of a broad range of biomolecular interactions, one molecule at a time, to characterize the molecular dynamics of processes as diverse as glycoprotein cross-linking, amyloidogenic protein aggregation, and actin polymerization.
Quantifying the heterogeneity of macromolecular machines by mass photometry.
Adar Sonn-Segev,Katarina Belacic,Tatyana Bodrug,Gavin Young,Ryan T. VanderLinden,Brenda A. Schulman,Brenda A. Schulman,Johannes Schimpf,Thorsten Friedrich,Phat Vinh Dip,Thomas U. Schwartz,Benedikt Bauer,Jan-Michael Peters,Weston B. Struwe,Justin L. P. Benesch,Nicholas G. Brown,David Haselbach,Philipp Kukura +17 more
TL;DR: It is shown that mass photometry can accurately characterize the heterogeneity of a sample using minimal material with high resolution within a matter of minutes, with implications for structural studies specifically and in vitro studies more generally.
Label-Free Single-Molecule Imaging with Numerical-Aperture-Shaped Interferometric Scattering Microscopy
TL;DR: In this article, a partially transmissive spatial mask placed near the back focal plane of a high numerical aperture microscope objective was shown to enhance the extinction contrast of a scatterer near an interface by approximately T 1/2, where T is the transmissivity of the mask.
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Structural dynamics of myosin 5 during processive motion revealed by interferometric scattering microscopy
Joanna Andrecka,Jaime Ortega Arroyo,Yasuharu Takagi,Gabrielle de Wit,Adam Fineberg,Lachlan MacKinnon,Gavin Young,James R. Sellers,Philipp Kukura +8 more
TL;DR: These results visualize many of the critical unknown aspects of the stepping mechanism of myosin 5 including head–head coordination, the origin of lever-arm motion and the spatiotemporal dynamics of the translocating head during individual steps.
Dissecting FOXP2 Oligomerization and DNA Binding.
TL;DR: A combined biochemical and biophysical approach was used to characterize the DNA binding and protein oligomerization of the transcription factor, forkhead box protein P2 (FOXP2), and found that the LZ mediates FOXP2 dimerization via coiled‐coil formation but also contributes to DNA binding.
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