Gavin McLaughlin
Athlone Institute of Technology
16 Papers
114 Citations
Gavin McLaughlin is an academic researcher from Athlone Institute of Technology. The author has contributed to research in topics: Monoamine transporter & Monoamine neurotransmitter. The author has an hindex of 10, co-authored 16 publications. Previous affiliations of Gavin McLaughlin include Trinity College, Dublin.
Chat about Author
Papers
Test purchase, synthesis, and characterization of 2-methoxydiphenidine (MXP) and differentiation from its meta- and para-substituted isomers
Gavin McLaughlin,Noreen Morris,Pierce V. Kavanagh,John D. Power,John E. O'Brien,Brian Talbot,Simon P. Elliott,Jason Wallach,Khoa Hoang,Hamilton Morris,Simon D. Brandt +10 more
TL;DR: Analytical data obtained for the three purchased samples were consistent with the synthesized 2-MXP standard and the differentiation between the isomers was possible, and distinct stability differences were observed for all three isomers during in-source collision-induced dissociation of the protonated molecule.
Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone
Gavin McLaughlin,Noreen Morris,Pierce V. Kavanagh,John D. Power,Geraldine Dowling,Brendan Twamley,John E. O'Brien,Brian Talbot,Donna Walther,John S. Partilla,Michael H. Baumann,Simon D. Brandt +11 more
TL;DR: The isomer N-methoxymephedrone was found to be a weak uptake blocker at DAT, NET and SERT, as well as a fully efficacious substrate-type releasing agent across all three transporters with EC50 values in the low micromolar range.
Preparation and characterization of the ‘research chemical’ diphenidine, its pyrrolidine analogue, and their 2,2‐diphenylethyl isomers
Jason Wallach,Pierce V. Kavanagh,Gavin McLaughlin,Noreen Morris,John D. Power,Simon P. Elliott,Marion S. Mercier,David Lodge,Hamilton Morris,Nicola M. Dempster,Simon D. Brandt +10 more
TL;DR: 1,2- diphenylethylamines appears to reflect the exploration of alternatives to arylcyclohexylamine-type substances, such as methoxetamine, PCP and PCPy-based analogues that also show NMDA receptor activity as demonstrated here for diphenidine.
In vitro metabolism of the synthetic cannabinoid 3,5‐AB‐CHMFUPPYCA and its 5,3‐regioisomer and investigation of their thermal stability
Florian Franz,Verena Angerer,Simon D. Brandt,Gavin McLaughlin,Pierce V. Kavanagh,Bjoern Moosmann,Volker Auwärter +6 more
TL;DR: Biotransformation to monohydroxylated metabolites of high abundance confirmed that these species might serve as suitable targets for urine analysis and the stability of both isomers was assessed under smoking conditions.
The pharmacokinetic interaction between ivacaftor and ritonavir in healthy volunteers.
TL;DR: The data suggest that ritonavir may be used to inhibit the metabolism of ivacaftor in patients with cystic fibrosis (CF).
19