Gavin M. Bendle
Netherlands Cancer Institute
23 Papers
317 Citations
Gavin M. Bendle is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 14, co-authored 20 publications. Previous affiliations of Gavin M. Bendle include University of Birmingham.
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Papers
Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers
Wouter Scheper,Sander Kelderman,Lorenzo F. Fanchi,Carsten Linnemann,Gavin M. Bendle,Marije A. J. de Rooij,Christian Hirt,Riccardo Mezzadra,Maarten Slagter,Krijn K. Dijkstra,Roelof J.C. Kluin,Petur Snaebjornsson,Katy Milne,Brad H. Nelson,Henry Zijlmans,Gemma G. Kenter,Emile E. Voest,John B. A. G. Haanen,Ton N. Schumacher +18 more
TL;DR: The intrinsic tumor reactivity of the intratumoral TCR repertoire of CD8+ T cells in ovarian and colorectal cancer is analyzed to indicate that the intrinsic capacity of intrumoral T cells to recognize adjacent tumor tissue can be rare and variable, and suggest that clinical efforts to reactivate intratumor T cells will benefit from approaches that simultaneously increase the quality of the intruder's TCR repertoires.
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High-throughput identification of antigen-specific TCRs by TCR gene capture
Carsten Linnemann,Bianca Heemskerk,Pia Kvistborg,Roelof J.C. Kluin,Dmitriy A. Bolotin,Xiaojing Chen,Kaspar Bresser,Marja Nieuwland,Remko Schotte,Samira Michels,Raquel Gomez-Eerland,Lorenz Jahn,Pleun Hombrink,Nicolas Legrand,Chengyi Jenny Shu,Ilgar Z. Mamedov,Arno Velds,Christian U. Blank,John B. A. G. Haanen,Maria A. Turchaninova,Ron M. Kerkhoven,Hergen Spits,Sine Reker Hadrup,Mirjam H.M. Heemskerk,Thomas Blankenstein,Dmitriy M. Chudakov,Gavin M. Bendle,Ton N. Schumacher +27 more
TL;DR: The ability to identify tumor-reactive TCRs within intratumoral T cell subsets without knowledge of antigen specificities is demonstrated, which may be the first step toward the development of autologous TCR gene therapy to target patient-specific neoantigens in human cancer.
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A critical role of T cell antigen receptor-transduced MHC class I-restricted helper T cells in tumor protection
TL;DR: In vivo synergy between T cell antigen receptor-transduced CD4+ and CD8+ T cells specific for the same epitope resulting in long-term tumor protection is demonstrated.
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Requirements for Effective Antitumor Responses of TCR Transduced T Cells
Moniek A. de Witte,Annelies Jorritsma,Andrew Kaiser,Marly D. van den Boom,Maarten Dokter,Gavin M. Bendle,John B. A. G. Haanen,Ton N. Schumacher +7 more
TL;DR: TCR gene therapy can achieve a sufficiently strong selective pressure to warrant the simultaneous targeting of multiple Ags, and should be of value to enhance the antitumor activity of TCR-modified T cells in clinical trials.
Preclinical development of T cell receptor gene therapy.
TL;DR: In which areas pre clinical studies in mouse models can or cannot be expected to be of value to guide clinical trial design, and how the available data from preclinical studies should influence forthcoming clinical trials are discussed.
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