Gavin D. Richardson
Newcastle University
53 Papers
65 Citations
Gavin D. Richardson is an academic researcher from Newcastle University. The author has contributed to research in topics: Medicine & Senescence. The author has an hindex of 19, co-authored 37 publications. Previous affiliations of Gavin D. Richardson include Centre for Life & Freeman Hospital.
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Papers
CD133, a novel marker for human prostatic epithelial stem cells
Gavin D. Richardson,Craig N. Robson,S. Lang,David E. Neal,Norman J. Maitland,A. Collins +5 more
TL;DR: CD133 is a novel marker for human prostatic epithelial stem cells that exhibits high proliferative potential and can reconstitute prostatic-like acini.
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Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
Rhys Anderson,Anthony B. Lagnado,Damien Maggiorani,Anna Walaszczyk,Emily Dookun,James Chapman,Jodie Birch,Hanna Salmonowicz,Mikolaj Ogrodnik,Diana Jurk,Diana Jurk,Carole J. Proctor,Clara Correia-Melo,Stella Victorelli,Edward Fielder,Rolando Berlinguer-Palmini,A Owens,Laura C. Greaves,Kathy L Kolsky,Angelo Parini,Victorine Douin-Echinard,Nathan K. LeBrasseur,Helen M. Arthur,Simon Tual-Chalot,Marissa J. Schafer,Carolyn M Roos,Jordan D. Miller,Neil Robertson,Jelena Mann,Peter D. Adams,Peter D. Adams,Tamara Tchkonia,James L. Kirkland,Jeanne Mialet-Perez,Gavin D. Richardson,João F. Passos,João F. Passos +36 more
TL;DR: A mechanism by which senescence can occur and contribute to age‐related myocardial dysfunction and in the wider setting to ageing in post‐mitotic tissues is described.
Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction.
Anna Walaszczyk,Emily Dookun,Rachael Redgrave,Simon Tual-Chalot,Stella Victorelli,Stella Victorelli,Ioakim Spyridopoulos,A Owens,Helen M. Arthur,João F. Passos,João F. Passos,Gavin D. Richardson +11 more
TL;DR: It is demonstrated that treatment of aged mice with the senolytic drug, navitoclax, eliminates senescent cardiomyocytes and attenuates profibrotic protein expression in aged mice, and clearance of senescent cells improved myocardial remodelling and diastolic function as well as overall survival following MI.
Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery.
Emily Dookun,Anna Walaszczyk,Rachael Redgrave,Pawel Palmowski,Simon Tual-Chalot,Averina Suwana,James Chapman,Eduard Jirkovsky,Leticia Donastorg Sosa,Eleanor K Gill,Oliver E Yausep,Yohan Santin,Jeanne Mialet-Perez,W. Andrew Owens,David J. Grieve,Ioakim Spyridopoulos,Michael J. Taggart,Helen M. Arthur,João F. Passos,Gavin D. Richardson +19 more
TL;DR: It is demonstrated that IRI induces cellular senescence in both cardiomyocytes and interstitial cell populations and treatment with the senolytic drug navitoclax after ischemia–reperfusion improves left ventricular function, increases myocardial vascularization, and decreases scar size.
Modelling the hair follicle dermal papilla using spheroid cell cultures.
Claire A. Higgins,Gavin D. Richardson,Dudley Ferdinando,Gillian E. Westgate,Colin A.B. Jahoda +4 more
TL;DR: Modelling the hair follicle dermal papilla using spheroid cell cultures with real-time PCR is shown to be a simple and straightforward process.
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