Gavin Carr
Harvard University
11 Papers
9 Citations
Gavin Carr is an academic researcher from Harvard University. The author has contributed to research in topics: Chemistry & Burkholderia thailandensis. The author has an hindex of 7, co-authored 11 publications.
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Papers
Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.
TL;DR: Three new members of the angucycline class of antibiotics, pseudonocardones A–C (1–3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum.
Microtermolides A (I) and B (II) from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin.
Gavin Carr,Michael Poulsen,Jonathan L. Klassen,Yanpeng Hou,Thomas P. Wyche,Tim S. Bulgni,Cameron R. Currie,Jon Clardy +7 more
TL;DR: In this article, the title compounds are isolated and characterized, but no absolute configuration is determined, and no absolute configurations of the compounds can be determined for any given class of compounds.
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Bactobolin Resistance Is Conferred by Mutations in the L2 Ribosomal Protein
Josephine R. Chandler,Thao T. Truong,Patricia M. Silva,Mohammad R. Seyedsayamdost,Gavin Carr,Matthew C. Radey,Michael A. Jacobs,Elizabeth H. Sims,Jon Clardy,E. Peter Greenberg +9 more
TL;DR: The data indicate that bactobolins target the L2 protein or a nearby site and that this is not the target of other antibiotics, and that the mammalian target of bactOBolins involves the eukaryotic homolog of L8e.
Sources of Diversity in Bactobolin Biosynthesis by Burkholderia thailandensis E264
TL;DR: A series of deletion mutants in the recently identified bactobolin biosynthetic pathway defined the roles of several key biosynthesis enzymes and showed how promiscuity in three enzyme systems allows this cluster to produce multiple products.
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Patent
Substituted quinone indoleamine 2,3-dioxygenase (ido) inhibitors and syntheses and uses therefor
Raymond Andersen,Michael Leblanc,Harry C. Brastianos,Eduardo Vottero,Michel Roberge,Grant Mauk,Gavin Carr +6 more
- 02 Nov 2007
TL;DR: In this article, the present invention relates to substituted mdoloqumone compounds of the general formula (A and B) and pharmaceutical compositions thereof that are inhibitors of mdoleamme-2,3-dioxygenase (IDO).
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