Gary S. Ma
University of California, San Diego
15 Papers
30 Citations
Gary S. Ma is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 5, co-authored 9 publications.
Chat about Author
Papers
Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.
Krishna Midde,Nicolas Aznar,Melanie B. Laederich,Gary S. Ma,Maya T. Kunkel,Alexandra C. Newton,Pradipta Ghosh +6 more
TL;DR: Modular fluorescent biosensors that exploit the remarkable specificity of bimolecular recognition are developed that provide direct evidence that RTK–GIV–Gαi ternary complexes are formed in living cells and that Gαi is transactivated within minutes after growth factor stimulation at the plasma membrane.
Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors.
Gary S. Ma,Nicolas Aznar,Nicholas A. Kalogriopoulos,Krishna Midde,Inmaculada Lopez-Sanchez,Emi Sato,Ying Dunkel,Richard L. Gallo,Pradipta Ghosh,Pradipta Ghosh +9 more
TL;DR: TAT-GIV peptides provide a novel and versatile tool to manipulate Gαi activation downstream of growth factors in a diverse array of pathophysiologic conditions and enhance the complex, multireceptor-driven process of wound repair in mice in a GEF-dependent manner.
42
Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity.
Gary S. Ma,Inmaculada Lopez-Sanchez,Nicolas Aznar,Nicholas A. Kalogriopoulos,Shabnam Pedram,Krishna Midde,Theodore P. Ciaraldi,Robert R. Henry,Pradipta Ghosh,Pradipta Ghosh +9 more
TL;DR: It is shown that activation of Gαi by GIV/Girdin is a decisive event within the metabolic insulin signaling cascade that reversibly orchestrates insulin sensitivity or resistance.
GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles
Inmaculada Lopez-Sanchez,Gary S. Ma,Shabnam Pedram,Nicholas A. Kalogriopoulos,Pradipta Ghosh +4 more
TL;DR: It is shown that GIV directly and constitutively binds the exocyst complex subunit Exo-70 and also associates with GLUT4-storage vesicles (GSVs) exclusively upon insulin stimulation, suggesting a role of GIV in coordinating key signaling and trafficking events of metabolic insulin response.
15
Lipoprotein(a) in Patients Undergoing Transcatheter Aortic Valve Replacement.
Gary S. Ma,Michael J. Wilkinson,Ryan Reeves,Calvin Yeang,Anthony N. DeMaria,Bruno Cotter,Mitul Patel,Ehtisham Mahmud,Sotirios Tsimikas +8 more
TL;DR: This study defines the prevalence of elevated Lp(a) in advanced stages of CAVS and provides a practice pathway to assess procedural complications and long-term outcomes of TAVR in patients with Elevated Lp (a) levels.
12