Gary S. David
University of Texas MD Anderson Cancer Center
5 Papers
342 Citations
Gary S. David is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Monoclonal antibody & Antibody. The author has an hindex of 5, co-authored 5 publications.
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Papers
•Journal Article
Stability, Characterization, and Kinetics of 111In-labeled Monoclonal Antitumor Antibodies in Normal Animals and Nude Mouse-Human Tumor Models
Samuel E. Halpern,Phillip L. Hagan,P. Garver,James A. Koziol,Agnes Chen,James M. Frincke,Richard M. Bartholomew,Gary S. David,Adams Thomas Henry +8 more
TL;DR: The data indicate that 111In-MoAb may prove to be effective as a radiopharmaceutical for tumor imaging and follow a two-compartmental model when studied in nude mice bearing human colon tumors known to express carcinoembryonic antigen.
209
•Journal Article
Tumor Size: Effect on Monoclonal Antibody Uptake in Tumor Models
Phillip L. Hagan,Samuel E. Halpern,Robert O. Dillman,D L Shawler,Duane E. Johnson,Agnes Chen,L Krishnan,James M. Frincke,Richard M. Bartholomew,Gary S. David +9 more
TL;DR: There is strong evidence for a decrease in per g uptake of labeled tumor specific antibodies as tumors increase in size.
145
•Journal Article
Modification of Human Leukocyte Interferon Pharmacology with a Monoclonal Antibody
Michael G. Rosenblum,Barbara W. Unger,Jordan U. Gutterman,Evan M. Hersh,Gary S. David,James M. Frincke +5 more
TL;DR: It is suggested that interferon bound to a monoclonal antibody may provide a means to prevent the normal clearance and degradation of free interferons and may result in prolonged antitumor and antiviral plasma activity in vivo.
68
•Journal Article
Distribution of radiolabeled human and mouse monoclonal IgM antibodies in murine models.
Samuel E. Halpern,Philip Hagan,Agnes Chen,Charles R. Birdwell,Richard M. Bartholomew,Karen G. Burnett,Gary S. David,Kenneth Poggenburg,Bruce Merchant,Dennis J. Carlo +9 more
TL;DR: The human imaging indicates that it is possible to target tumor with human IgM MoAbs, but significant problems remain in regard to their clinical use.
16
•Journal Article
Radioimmunoimaging in malignant melanoma with 111In-labeled monoclonal antibody 96.5.
James L. Murray,Michael G. Rosenblum,Carl Plager,T. P. Haynie,Monroe F. Jahns,Howard J. Glenn,Lamk Lamki,Robert S. Benjamin,Nicholas Papadopoulos,Arthur W. Boddie,Evan M. Hersh,Robert E. Sobol,Richard M. Bartholomew,James M. Frincke,Gary S. David,Dennis J. Carlo +15 more
TL;DR: Tumor imaging of melanoma using 111In-labeled monoclonal antibody 96.5 appeared feasible, especially at antibody doses above 2 mg, although background uptake of isotope was observed in blood pool and other organs with gradual acquisition of label by 48 to 72 h.