Gary Meyerrose

TL;DR: This molecular target approach may facilitate the in vivo noninvasive imaging of atherosclerotic lesions in terms of intimal macrophage accumulation and distribution and disclose lesion features related to inflammation and possibly vulnerability thereby facilitate early lesion detection and targeted delivery of therapeutic compounds to intimal Macrophages.

TL;DR: Spironolactone prevents age‐related increases in myocardial fibrosis in old normotensive rats and helps restore diastolic function in the elderly.

TL;DR: This investigation into the importance of ACE inhibitor tissue penetration on a common marker of vascular inflammation, suggests a potential vascular anti-inflammatory benefit with a more highly tissue penetrating ACE inhibitor following AMI.

TL;DR: Aldosterone antagonists inhibit the deposition of collagen matrix in the myocardium, thereby targeting the basic pathophysiological mechanism of diastolic dysfunction, and appear to represent a promising therapeutic approach for this condition.