Gary Eichenbaum
Johnson & Johnson Pharmaceutical Research and Development
10 Papers
88 Citations
Gary Eichenbaum is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Solubility & Gastric emptying. The author has an hindex of 6, co-authored 10 publications.
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Papers
Assessment of the genotoxic and carcinogenic risks of p-nitrophenol when it is present as an impurity in a drug product
Gary Eichenbaum,Mark D. Johnson,David Kirkland,P. O’Neill,S. Stellar,J. Bielawne,R. DeWire,D. Areia,S. Bryant,S. Weiner,Daksha Desai-Krieger,P. Guzzie-Peck,David C. Evans,A. Tonelli +13 more
TL;DR: Results indicate that p-nitrophenol should be considered a non-genotoxic impurity and, as a drug impurity, a threshold limit of 4 mg/day would be set (per ICH Q3C).
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Gavage-Related Reflux in Rats Identification, Pathogenesis, and Toxicological Implications (Review)
Siegrid Damsch,Gary Eichenbaum,Alfred Tonelli,L. Lammens,Kathleen Van den Bulck,Bianca Feyen,John Vandenberghe,Anton Megens,Elaine Knight,Kelley Michael F +9 more
TL;DR: The article aims to increase the awareness and understanding of the pathogenesis of gavage-related reflux and provides guidance on identification of potential risk factors, as well as interpretation of histological changes and their toxicological relevance.
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Parallel screening approach to identify solubility-enhancing formulations for improved bioavailability of a poorly water-soluble compound using milligram quantities of material.
TL;DR: The results in the study suggest that this parallel screening assay can be potentially used to rapidly identify solubility-enhancing formulations for an improved bioavailability of poorly water-soluble compounds using milligram quantities of material.
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Screening Method to Identify Preclinical Liquid and Semi‐Solid Formulations for low Solubility Compounds: Miniaturization and Automation of Solvent Casting and Dissolution Testing
TL;DR: An efficient screening method to identify liquid and semisolid formulations for low-solubility compounds is developed, which generated the highest and most stable kinetic solubility upon dilution.
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Impact of gavage dosing procedure and gastric content on adverse respiratory effects and mortality in rat toxicity studies
Gary Eichenbaum,Siegrid Damsch,Adriana Looszova,John Vandenberghe,K. Van den Bulck,Karen Roels,Anton Megens,Elaine Knight,V. Hillsamer,Bianca Feyen,Kelley Michael F,Alfred Tonelli,L. Lammens +12 more
TL;DR: Reducing the dose volume and dosing fasted animals substantially reduced or eliminated the respiratory effects and mortality at the high test article concentrations, demonstrating that the adverse effects are related to the gavage method.
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