Gary DiPerna
University of Massachusetts Medical School
2 Papers
Gary DiPerna is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Immune receptor & MDA5. The author has an hindex of 2, co-authored 2 publications.
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Papers
Poxvirus Protein N1L Targets the I-κB Kinase Complex, Inhibits Signaling to NF-κB by the Tumor Necrosis Factor Superfamily of Receptors, and Inhibits NF-κB and IRF3 Signaling by Toll-like Receptors
Gary DiPerna,Julianne Stack,Andrew G. Bowie,Annemarie Boyd,Girish J. Kotwal,Girish J. Kotwal,Zhouning Zhang,Sheila Arvikar,Eicke Latz,Katherine A. Fitzgerald,William L. Marshall,William L. Marshall +11 more
TL;DR: A role is defined for N1L as an immunomodulator of innate immunity by targeting components of NF-κB and IRF3 signaling pathways, which are consistent with the hypothesis that N 1L disrupts signaling to NF-π by Toll/IL-1Rs and TNF superfamily receptors by targeting the IKK complex for inhibition.
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The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I
Simon Rothenfusser,Nadege Goutagny,Gary DiPerna,Mei Gong,Brian G. Monks,Annett Schoenemeyer,Masahiro Yamamoto,Shizuo Akira,Katherine A. Fitzgerald +8 more
TL;DR: It is proposed that Lgp2 acts as a negative feedback regulator of antiviral signaling by sequestering dsRNA from RIG-I, and inhibits SV and Newcastle disease virus signaling to IFN-stimulated regulatory element- and NF-κB-dependent pathways.