Gary D. Lopaschuk
University of Alberta
417 Papers
3.3K Citations
Gary D. Lopaschuk is an academic researcher from University of Alberta. The author has contributed to research in topics: Beta oxidation & Heart failure. The author has an hindex of 96, co-authored 387 publications. Previous affiliations of Gary D. Lopaschuk include Cornell University & University of British Columbia.
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Papers
Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure
Golam M. Uddin,Liyan Zhang,Saumya Shah,Arata Fukushima,Cory S. Wagg,Keshav Gopal,Rami Al Batran,Simran Pherwani,Kim L. Ho,Jamie Boisvenue,Qutuba G. Karwi,Qutuba G. Karwi,Tariq R. Altamimi,David S. Wishart,Jason R.B. Dyck,John R. Ussher,Gavin Y. Oudit,Gary D. Lopaschuk +17 more
TL;DR: It is concluded that impaired cardiac BCAA catabolism and insulin signaling occur in human heart failure, while enhancing BCAA oxidation can improve cardiac function in the failing mouse heart.
Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload
Pavel Zhabyeyev,Manoj Gandhi,Jun Mori,Ratnadeep Basu,Zamaneh Kassiri,Alexander S. Clanachan,Gary D. Lopaschuk,Gavin Y. Oudit +7 more
TL;DR: Normalizing the balance between metabolic substrate utilization may alleviate pressure-overload-induced heart failure and ischaemia and shift the preference of substrate oxidation from glucose and lactate to fatty acid due to a selective reduction in carbohydrate oxidation.
Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation.
TL;DR: The results suggest that the beneficial effects of carnitine in the ischemic heart can be explained by the actions of this compound on overcoming fatty acid inhibition of glucose oxidation.
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Targeting mitochondrial oxidative metabolism as an approach to treat heart failure.
TL;DR: While targeting mitochondrial oxidative metabolism is a promising strategy to treat heart failure, further studies are needed to confirm the potential beneficial effect of modulating these metabolic targets as an approach to treating heart failure.
130
Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders
Zhimin Chen,Guoxiao Wang,Sara L. Ma,Dae Young Jung,Hyekyung Ha,Tariq R. Altamimi,Xu Yun Zhao,Liang Guo,Peng Zhang,Chun-Rui Hu,Ji-Xin Cheng,Gary D. Lopaschuk,Jason K. Kim,Jiandie D. Lin +13 more
TL;DR: Nrg4 exerts pleiotropic beneficial effects on energy balance and glucose and lipid metabolism to ameliorate obesity-associated metabolic disorders and may improve both type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) in patients.
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