Gary Adamson
UCL Institute of Neurology
22 Papers
32 Citations
Gary Adamson is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: PRNP & Population. The author has an hindex of 14, co-authored 22 publications. Previous affiliations of Gary Adamson include University College London & Medical Research Council.
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Papers
Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population.
Jon Beck,Mark Poulter,Davina Hensman,Jonathan D. Rohrer,Colin J. Mahoney,Gary Adamson,Tracy Campbell,James Uphill,Aaron J. Borg,Pietro Fratta,Richard W. Orrell,Andrea Malaspina,James B. Rowe,Jeremy M Brown,John R. Hodges,John R. Hodges,John R. Hodges,Katie Sidle,James M. Polke,Henry Houlden,Jonathan M. Schott,Nick C. Fox,Martin N. Rossor,Sarah J. Tabrizi,Adrian M. Isaacs,John Hardy,Jason D. Warren,John Collinge,Simon Mead +28 more
TL;DR: Evidence of instability of repeat size in control families, as well as neighboring SNP and microsatellite analyses, support multiple expansion events on the same haplotype background and the method of estimating the size of large expansions has potential clinical utility.
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FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration.
Hazel Urwin,Keith A. Josephs,Jonathan D. Rohrer,Ian R. A. Mackenzie,Manuela Neumann,Astrid Authier,Harro Seelaar,John C. van Swieten,Jeremy M Brown,Peter Johannsen,Jørgen E. Nielsen,Ida E. Holm,Dennis W. Dickson,Rosa Rademakers,Neill R. Graff-Radford,Joseph E. Parisi,Ronald C. Petersen,Kimmo J. Hatanpaa,Charles L. White,Myron F. Weiner,Felix Geser,Vivianna M. Van Deerlin,John Q. Trojanowski,Bruce L. Miller,William W. Seeley,Julie van der Zee,Julie van der Zee,Samir Kumar-Singh,Samir Kumar-Singh,Sebastiaan Engelborghs,Peter Paul De Deyn,Christine Van Broeckhoven,Christine Van Broeckhoven,Eileen H. Bigio,Han Xiang Deng,Glenda M. Halliday,Jillian J. Kril,David G. Munoz,David M. A. Mann,Stuart Pickering-Brown,Valerie Doodeman,Gary Adamson,Shabnam Ghazi-Noori,Elizabeth M. C. Fisher,Janice L. Holton,Tamas Revesz,Martin N. Rossor,John Collinge,Simon Mead,Adrian M. Isaacs +49 more
TL;DR: The first comprehensive analysis of these FTLD-FUS cases is presented, in terms of neuropathology, genetics, demographics and clinical data, suggesting that the full complement of FTLD pathologies is yet to be elucidated.
Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series
Natalie S. Ryan,Jennifer M. Nicholas,Jennifer M. Nicholas,Philip S.J. Weston,Yuying Liang,Tammaryn Lashley,Rita Guerreiro,Rita Guerreiro,Gary Adamson,Janna Kenny,Jon Beck,Lucía Chávez-Gutiérrez,Bart De Strooper,Bart De Strooper,Tamas Revesz,Janice L. Holton,Simon Mead,Martin N. Rossor,Nick C. Fox +18 more
TL;DR: The importance of considering genetic testing in young patients with dementia and additional neurological features in order to appropriately diagnose and treat their symptoms is highlighted, and of examining different mutation types separately in future research is highlighted.
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Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series
Thomas E.F. Webb,Mark Poulter,John Beck,James Uphill,Gary Adamson,Thomas B. Campbell,Jacqueline M. Linehan,Caroline Powell,Sebastian Brandner,Suvankar Pal,D. Siddique,Jonathan D. F. Wadsworth,Susan Joiner,K. Alner,C. Petersen,S. Hampson,C. Rhymes,Colm Treacy,Elsdon Storey,Michael D. Geschwind,Andrea H. Németh,Stephen J. Wroe,John Collinge,Simon Mead +23 more
TL;DR: Data from 84 patients in the large UK kindred and numerous small unrelated pedigrees is collected to investigate phenotypic heterogeneity and modifying factors and shows that polymorphic human prion protein gene codon 129 modifies age at onset, showing an appreciation of the range of clinical phenotype, modern imaging and molecular investigation and should inform genetic counselling of at-risk individuals.
R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia.
Catherine F. Slattery,Jon Beck,Lorna Harper,Gary Adamson,Zeinab Abdi,James Uphill,Tracy Campbell,Ron Druyeh,Colin J. Mahoney,Jonathan D. Rohrer,Janna Kenny,Jessica Lowe,Kelvin K. Leung,Josephine Barnes,Shona Clegg,Melanie Blair,Jennifer M. Nicholas,Rita Guerreiro,James B. Rowe,Claudia Ponto,Inga Zerr,Hans A. Kretzschmar,Pierluigi Gambetti,Sebastian J. Crutch,Jason D. Warren,Martin N. Rossor,Nick C. Fox,John Collinge,Jonathan M. Schott,Simon Mead +29 more
TL;DR: Rare TREM2 variants are significant risk factors for Alzheimer's disease (AD) and should be considered as a major risk factor for the disease.