Gaofeng Chen
Shanghai University
35 Papers
118 Citations
Gaofeng Chen is an academic researcher from Shanghai University. The author has contributed to research in topics: Medicine & Hepatic stellate cell. The author has an hindex of 10, co-authored 23 publications. Previous affiliations of Gaofeng Chen include Chinese Ministry of Education.
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Papers
Effects of Yinchenhao Tang and related decoctions on DMN-induced cirrhosis/fibrosis in rats
TL;DR: Among the five Chinese medicine decoctions, YCHT exerted the most significant therapeutic effects on DMN-induced cirrhosis/fibrosis in rats.
Inhibition of notch signaling pathway prevents cholestatic liver fibrosis by decreasing the differentiation of hepatic progenitor cells into cholangiocytes
Xiao Zhang,Guang-Li Du,Ying Xu,Xuewei Li,Weiwei Fan,Jiamei Chen,Cheng Liu,Gaofeng Chen,Cheng-Hai Liu,Mark A. Zern,Yongping Mu,Ping Liu +11 more
TL;DR: It is revealed that notch signaling activation is required for HPC differentiation into cholangiocytes in CLF, and inhibition of the Notch signaling pathway may offer a therapeutic approach for treating CLF.
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Huangqi decoction inhibits apoptosis and fibrosis, but promotes Kupffer cell activation in dimethylnitrosamine-induced rat liver fibrosis
Cheng Liu,Gaoqiang Wang,Gaofeng Chen,Yongping Mu,Li-jun Zhang,Xu-dong Hu,Mingyu Sun,Cheng-Hai Liu,Ping Liu +8 more
TL;DR: HQD exhibited positive protective effects against liver fibrosis; its mechanism of action was associated with protection from hepatocyte apoptosis and the promotion of CD68 expression in the devolopment of Liver fibrosis to cirrhosis development.
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Ingredients of Huangqi decoction slow biliary fibrosis progression by inhibiting the activation of the transforming growth factor-beta signaling pathway
Jin-xing Du,Mingyu Sun,Guang-Li Du,Fenghua Li,Cheng Liu,Yongping Mu,Gaofeng Chen,Ai-Hua Long,Yanqin Bian,Jia Liu,Cheng-Hai Liu,Yi-Yang Hu,Lie-Ming Xu,Ping Liu +13 more
TL;DR: IHQD exert significant therapeutic effects on BDL-induced fibrosis in rats through inhibition of the activation of TGF β1-Smad3 and TGFβ1-ERK1/2 signaling pathways.
Astragaloside prevents BDL-induced liver fibrosis through inhibition of notch signaling activation.
Mu Yongping,Xiao Zhang,Li Xuewei,Weiwei Fan,Jiamei Chen,Hua Zhang,Gaofeng Chen,Cheng-Hai Liu,Ping Liu +8 more
TL;DR: Astragaloside (AS) is a main component of Radix Astragali and had an effect similar to the Huangqi decoction on hepatic fibrosis, indicating that AS may be a potential therapeutic drug for cholestatic liver disease.
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