The present invention discloses the compounds of formula ( I ) or a pharmaceutically acceptable derivative, salt or prodrug thereof, which can inhibit HIV replication.

Pyrollidine-based compounds

The invention discloses castor oil micro-emulsion composition for coating a Nifeviroc anti-cancer medicine and a preparation method thereof. The composition comprises the following components in percentage by mass: 0.1 to 0.3 percent of Nifeviroc, 1 to 3 percent of lipid material, 3 to 9 percent of emulsifier, 1.5 to 4.5 percent of auxiliary emulsifier, 0.1 to 0.5 percent of bacteriostat and the balance of super-pure water. The micro-emulsion has high stability, high physiological compatibility and high safety. The preparation method is simple and controllable and has high repeatability. The castor oil micro-emulsion composition coated Nifeviroc anti-cancer medicine can prevent and treat acquired immune deficiency syndrome as a microbicide to be applied through vagina.

Castor oil micro-emulsion for Nifeviroc anti-cancer medicine and preparation method thereof

The invention relates to 2-p-luorobenzyl-3-hydroxy pyrrolidine amino acid, and a preparation method and the anticancer activity research thereof, and mainly solves the technical problem that the quantity of the class of compound is low. The compound has the structural formula as the figure shown in the description, wherein R is equal to various amino acids, and amino acids containing aromatic ring is optimized. The synthetic route of the amino acid is as shown in the description. The amino acid mainly inspects the influence on the activity of the class of the compound by groups with electric absorption being introduced in pyrrolidine 2-position.

2-p-luorobenzyl-3-hydroxy pyrrolidine amino acid, and preparation method and anticancer activity research thereof

The invention provides a compound and its preparing process, wherein the compound can be used for preparing medicament capable of effectively inhibiting or resisting HIV virus (such as HIV-I virus).

Compound for preparing nifeviroc and its preparing process

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Compound for preparing nifeviroc and its preparing process