Gang Jin
24 Papers
Gang Jin is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 18 publications.
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Papers
Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity
Xiaohan Shi,Yunguang Li,Qiuyue Yuan,Shijie Tang,Shiwei Guo,Yehan Zhang,Juan He,Xiaoyu Zhang,Ming Han,Zhuang Liu,Yiqin Zhu,Suizhi Gao,Huan Wang,Xiongfei Xu,Kailian Zheng,Wei Jing,Luonan Chen,Yong Wang,Gang Jin,Dong Gao +19 more
TL;DR: In this paper , the authors integrated the chromatin accessibility profiles of 84 pancreatic cancer organoid lines with whole-genome sequencing data, transcriptomic sequencing data and the results of drug sensitivity analysis of 283 epigenetic-related chemicals and 5 chemotherapeutic drugs.
Noninvasive detection of pancreatic ductal adenocarcinoma using the methylation signature of circulating tumour DNA
Huanwen M. Wu,Shiwei Guo,Xiaoding Liu,Yatong Li,Zhixi Su,Qiye He,Xiaoqian Liu,Zhiwen Zhang,Lianyuan Yu,Xiaohan Shi,Suizhi Gao,Huan Wang,Yaqi Pan,Chengcheng Ma,Rui Liu,Menghua Dai,Gang Jin,Zhiyong Liang +17 more
TL;DR: In this paper , a non-invasive test for early PDAC detection by capturing the circulating tumour DNA (ctDNA) methylation signature in blood was developed, which achieved an area under the curve (AUC) of 0.91 in both the validation and independent tests.
Metabolic classification suggests the GLUT1/ALDOB/G6PD axis as a therapeutic target in chemotherapy-resistant pancreatic cancer
Yunguang Li,Shijie Tang,Xiaohan Shi,Jingwen Lv,Xue-Ming Wu,Yehan Zhang,Huan Wang,Juan He,Yiqin Zhu,Yi Ju,Yajuan Zhang,Shiwei Guo,Weiwei Yang,Huiyong Yin,Luonan Chen,Dong Gao,Gang Jin +16 more
TL;DR: The findings uncover potential metabolic heterogeneity related to differences in chemotherapy sensitivity in PDAC and develop a promising pharmacological strategy for patients with chemotherapy-resistant glucomet-PDAC through the combination of chemotherapy and GLUT1/ALDOB/G6PD axis inhibitors.
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Functional hepatobiliary organoids recapitulate liver development and reveal essential drivers of hepatobiliary cell fate determination
Juan He,Haoyue Cui,Xiaohan Shi,Qiqi Jin,Ximeng Han,Tiantian Han,Jia-Shiou Peng,Shiwei Guo,Lei Zhang,Yun Zhao,Bin Zhou,Luonan Chen,Lei Chen,Yi Arial Zeng,Hongyang Wang,Gang Jin,Dong Gao +16 more
TL;DR: In this article , functional hepatobiliary organoids (HBOs) are generated from hepatocytes, which contain a bile duct network surrounded by mature hepatocytes and stably maintain hepatic characteristics and function in vitro and upon transplantation in vivo.
A multicenter, randomized, double-blind phase III clinical study to evaluate the efficacy and safety of KN046 combined with nab-paclitaxel and gemcitabine versus placebo combined with nab-paclitaxel and gemcitabine in patients with advanced pancreatic cancer (ENREACH-PDAC-01).
Gang Jin,Shiwei Guo,Jianming Xu,Rongrui Liu,Qianqian Liang,Yong Yang,Bao-Zhong Guo,Yiqi Xu,Binyan Xia,Chao Zhang,Shengxia Zhu,Tingting Xu +11 more
TL;DR: A phase III pivotal study is conducting now in China to verify the efficacy and safety of KN046 plus nab-paclitaxel and gemcitabine as first-line treatment for advanced pancreatic cancer (ENREACH-PDAC-01), with excellent preliminary results.
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