Gang Hu
Nanjing Medical University
218 Papers
844 Citations
Gang Hu is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Neuroprotection & Aquaporin 4. The author has an hindex of 50, co-authored 211 publications. Previous affiliations of Gang Hu include Nanjing University of Chinese Medicine & Nanjing Normal University.
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Papers
Antioxidant and anti-inflammatory effects of dexrazoxane on dopaminergic neuron degeneration in rodent models of Parkinson's disease.
Meng Mei,Yuanzhang Zhou,Mengdi Liu,Fangfang Zhao,Cong Wang,Jian-Hua Ding,Ming Lu,Gang Hu,Gang Hu +8 more
TL;DR: It is demonstrated for the first time that Dexrazoxane (Dex), a drug clinically used to reduce doxorubicin-induced cardiotoxicity in chemotherapy, can enter into midbrain and striatum through broken BBB in 6-hydroxydopamine- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced rodent models of PD.
Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake.
TL;DR: It is found that the repression of astroglial uptake function could be revived by GSH, and both Group II and III mGluR agonists could recover the endogenous reduced glutathione (GSH) level in LPS‐treated astrocytes, suggesting that the possible mechanisms of neuroprotection by either Type II or Type III mgluR activation may involve restoration of endogenous GSH.
ATP-sensitive potassium channel opener iptakalim protected against the cytotoxicity of MPP+ on SH-SY5Y cells by decreasing extracellular glutamate level
TL;DR: Results suggest KATP channel dysfunction may be involved in the mechanisms of MPP+‐induced cytotoxicity and iptakalim may modulate glutamate transporters and subsequently alleviate the increase of extracellular glutamate levels induced by MPP- through opening mitoKATP channels, thereby protecting SH‐SY5Y cells against MPP+.
Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124–2HG
Rongrong Huang,Yuan Zhang,Bing Han,Ying Bai,Rongbin Zhou,Guangming Gan,Jie Chao,Gang Hu,Honghong Yao +8 more
TL;DR: It is shown that the circular RNA HIPK2 (circHIPK2) functions as an endogenous microRNA-124 (MIR 124–2HG) sponge to sequester MIR124– 2HG and inhibit its activity, resulting in increased sigma non-opioid intracellular receptor 1 (SIGMAR1/OPRS1) expression.
Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin.
TL;DR: The evidence in this study suggests a role of DPP-IV in development of Type II diabetes, as well as in the combination of a high fat diet with an insulin deficiency.