Gal Haase
Weizmann Institute of Science
8 Papers
12 Citations
Gal Haase is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Wnt signaling pathway & Metastasis. The author has an hindex of 7, co-authored 8 publications.
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Papers
Wnt signaling in cancer stem cells and colon cancer metastasis.
TL;DR: Studies are described supporting a relationship between Wnt-regulated CSCs and the progression of CRC and these genes were identified as CRC markers.
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Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression
A Shvab,Gal Haase,Amir Ben-Shmuel,Nancy Gavert,Thomas Brabletz,Shoukat Dedhar,Avri Ben-Ze'ev +6 more
TL;DR: The secreted modular calcium-binding matricellular protein-2 (SMOC-2) was identified as a gene activated by L1-ezrin-NF-κB signaling and was localized at the bottom of normal human colonic crypts and at increased levels in CRC tissue with preferential expression in invasive areas of the tumor.
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c-Kit Is Suppressed in Human Colon Cancer Tissue and Contributes to L1-Mediated Metastasis
Nancy Gavert,Anna Shvab,Michal Sheffer,Amir Ben-Shmuel,Gal Haase,Eszter Bakos,Eytan Domany,Avri Ben-Ze'ev +7 more
TL;DR: Reconstituting c-Kit expression in L1-transfected cells blocked the biological effects conferred by L1 overexpression in driving motility and liver metastasis and provided insights into how colorectal cancer metastasizes to the liver.
34
Increased expression of cathepsin D is required for L1-mediated colon cancer progression.
TL;DR: The suppression of endogenous CTSD in L1-expressing cells blocked the increase in the proliferative, motile, tumorigenic and metastatic ability of CRC cells, suggesting the involvement of the Wnt/β-catenin pathway in C TSD expression.
ISG15 induction is required during L1-mediated colon cancer progression and metastasis.
Sanith Cheriyamundath,Sayon Basu,Gal Haase,Harry Doernberg,Nancy Gavert,Thomas Brabletz,Avri Ben-Ze'ev +6 more
TL;DR: The expression of interferon-stimulated gene 15 (ISG15) that operates much like ubiquitin, is elevated in the conditioned medium and in CRC cells overexpressing L1, suggesting that ISG15 is involved in L1-mediated CRC development and is a potential target for CRC therapy.