Gaël Nicolas

TL;DR: This study investigates the role of substance P and the NK1 receptor in aldosterone-producing adenomas, a common cause of primary aldosteronism, and finds that substance P stimulates aldosterone secretion in a subset of adenomas through the NK1 receptor.

TL;DR: It was shown that loss-of-function mutations in the ABCC4 gene, associated with leukemia outcome, altered the expression of the PEL antigen, which could open a new way toward drug dose adjustment for leukemia treatment.

TL;DR: It is demonstrated that induction of chronic hepcidin expression in 2-month-old Hfe-/- mice alters their pattern of cellular iron accumulation, leading to increased iron in tissue macrophages and duodenal cells but less iron in hepatocytes, and it is speculated that this change in iron homeostasis could offer a therapeutic advantage by protecting against damage to parenchymal cells.

TL;DR: In this paper , the authors performed whole-genome germline sequencing on 1644 sporadic cases and 3205 matched healthy elderly controls, using an extreme phenotype design, a combined rare-variant burden and ontologic analysis identified two sarcoma-specific pathways involved in mitotic and telomere functions.