Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events. The use of complementary approaches, including live-cell imaging, cell-free studies, X-ray crystallography and genetic studies in mice, has greatly advanced our understanding of the mechanisms by which dynamin acts, its essential roles in cell physiology and the specific function of different dynamin isoforms. In addition, several connections between dynamin and human disease have also emerged, highlighting specific contributions of this GTPase to the physiology of different tissues.

Dynamin, a membrane-remodelling GTPase

http://www.physiology.ucla.edu/images/lecture/NeherFlyer.pdf

Multiple roles of calcium ions in the regulation of neurotransmitter release.

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

The BAR Domain Superfamily: Membrane-Molding Macromolecules

Dynamin 1 is a neuron-specific guanosine triphosphatase thought to be critically required for the fission reaction of synaptic vesicle endocytosis. Unexpectedly, mice lacking dynamin 1 were able to form functional synapses, even though their postnatal viability was limited. However, during spontaneous network activity, branched, tubular plasma membrane invaginations accumulated, capped by clathrin-coated pits, in synapses of dynamin 1-knockout mice. Synaptic vesicle endocytosis was severely impaired during strong exogenous stimulation but resumed efficiently when the stimulus was terminated. Thus, dynamin 1-independent mechanisms can support limited synaptic vesicle endocytosis, but dynamin 1 is needed during high levels of neuronal activity.

https://science.sciencemag.org/content/sci/316/5824/570.full.pdf

A Selective Activity-Dependent Requirement for Dynamin 1 in Synaptic Vesicle Endocytosis

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A Selective Activity-Dependent Requirement for Dynamin 1 in Synaptic Vesicle Endocytosis