Gabi Tarcic
Weizmann Institute of Science
36 Papers
172 Citations
Gabi Tarcic is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Cancer & Epidermal growth factor. The author has an hindex of 13, co-authored 31 publications. Previous affiliations of Gabi Tarcic include Hebrew University of Jerusalem.
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Papers
A module of negative feedback regulators defines growth factor signaling.
Ido Amit,Ami Citri,Ami Citri,Tal Shay,Yiling Lu,Menachem Katz,Fan Zhang,Gabi Tarcic,Doris R. Siwak,John P. Lahad,Jasmine Jacob-Hirsch,Ninette Amariglio,Nora Vaisman,Eran Segal,Gideon Rechavi,Uri Alon,Gordon B. Mills,Eytan Domany,Yosef Yarden +18 more
TL;DR: This study addresses the dynamics of growth factor signaling through profiling of protein phosphorylation and gene expression, demonstrating the presence of a kinetically defined cluster of delayed early genes that function to attenuate the early events ofgrowth factor signaling.
525
A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration
Menachem Katz,Ido Amit,Ami Citri,Tal Shay,Silvia Carvalho,Sara Lavi,Fernanda Milanezi,Ljuba Lyass,Ninette Amariglio,Jasmine Jacob-Hirsch,Nir Ben-Chetrit,Gabi Tarcic,Moshit Lindzen,Roi Avraham,Yi Chun Liao,Patricia Trusk,Asya Lyass,Gideon Rechavi,Neil L. Spector,Su Hao Lo,Fernando Schmitt,Sarah S. Bacus,Yosef Yarden +22 more
TL;DR: This article showed that EGF downregulates tensin-3 expression and concomitantly upregates cten, a tensin family member that lacks the actin-binding domain.
201
EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF
Gabi Tarcic,Roi Avraham,Gur Pines,Ido Amit,Ido Amit,Tal Shay,Tal Shay,Yiling Lu,Yaara Zwang,Yaara Zwang,Menachem Katz,Menachem Katz,Nir Ben-Chetrit,Jasmine Jacob-Hirsch,Jasmine Jacob-Hirsch,Laura Virgilio,Laura Virgilio,Gideon Rechavi,George Mavrothalassitis,George Mavrothalassitis,Gordon B. Mills,Eytan Domany,Yosef Yarden +22 more
TL;DR: EGR1 and the EGF‐ERK‐ERF axis emerge from this study as major drivers of growth factor‐induced mammary cell migration in response to EGF.
137
EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic Transcription Factors
Roi Avraham,Aldema Sas-Chen,Ohad Manor,Israel Steinfeld,Reut Shalgi,Gabi Tarcic,Noa Bossel,Amit Zeisel,Ido Amit,Yaara Zwang,Espen Enerly,Hege G. Russnes,Francesca Biagioni,Marcella Mottolese,Sabrina Strano,Giovanni Blandino,Anne Lise Børresen-Dale,Yitzhak Pilpel,Zohar Yakhini,Zohar Yakhini,Eran Segal,Yosef Yarden +21 more
TL;DR: Specific microRNAs are identified as attenuators of growth factor signaling and oncogenesis, in line with roles as suppressors of EGF receptor (EGFR) signaling, which is decreased in breast and in brain tumors driven by the EGFR or the closely related HER2.
MHC class I-independent recognition of NK-activating receptor KIR2DS4.
Gil Katz,Roi Gazit,Tal I. Arnon,Tsufit Gonen-Gross,Gabi Tarcic,Gal Markel,Raizy Gruda,Hagit Achdout,Olga Drize,Sharon Merims,Ofer Mandelboim +10 more
TL;DR: It is shown that KIR2DS4 is able to also interact with a non-class I MHC protein expressed on melanoma cell lines and on a primary melanoma, and the amino acid residues involved in the recognition of this novel ligand are different from those interacting with HLA-Cw4.