G. Weeda
Leiden University
8 Papers
530 Citations
G. Weeda is an academic researcher from Leiden University. The author has contributed to research in topics: Nucleotide excision repair & Gene. The author has an hindex of 6, co-authored 8 publications.
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Papers
Adenosine deaminase: characterization and expression of a gene with a remarkable promoter.
Domenico Valerio,M. G. C. Duyvesteyn,B.M.M. Dekker,G. Weeda,Th.M. Berkvens,L. Van Der Voorn,H. van Ormondt,A. J. Van Der Eb +7 more
TL;DR: Cosmid clones containing the gene for human adenosine deaminase (ADA) were isolated and it was shown in a functional assay that a stretch of 135 bp immediately preceding the cap site has promoter activity.
314
Molecular cloning and biological characterization of the human excision repair gene ERCC-3.
G. Weeda,R. C. A. Van Ham,R. Masurel,Andries Westerveld,H. Odijk,J. de Wit,D. Bootsma,A. J. Van Der Eb,J. H. J. Hoeijmakers +8 more
TL;DR: The cloning, partial characterization, and preliminary studies of the biological activity of a human gene, designated ERCC-3, involved in early steps of the nucleotide excision repair pathway, deduce that the gene has a size of 35 to 45 kilobases, of which one essential segment has so far been refractory to cloning.
121
The cloned human DNA excision repair gene ERCC-1 fails to correct xeroderma pigmentosum complementation groups A through I.
M. van Duin,G. Vredeveldt,Lynne V. Mayne,Hanny Odijk,Wim Vermeulen,B. Klein,G. Weeda,J.H.J. Hoeijmakers,Dirk Bootsma,Andries Westerveld +9 more
TL;DR: The human DNA excision repair gene ERCC-1 complements the ultraviolet light (UV) and mitomycin C (MMC) sensitivity of CHO mutants of complementation group 1 by analyzing the endogenous gene in XP cells and by introducing the gene followed by repair assays as mentioned in this paper.
Mutational analysis of ERCC3, which is involved in DNA repair and transcription initiation: identification of domains essential for the DNA repair function.
Libin Ma,A. Westbroek,Aart G. Jochemsen,G. Weeda,A. Bosch,D. Bootsma,J. H. J. Hoeijmakers,A. J. Van Der Eb +7 more
TL;DR: The human ERCC3 gene, which corrects specifically the nucleotide excision repair defect in human xeroderma pigmentosum group B and cross-complements the repair deficiency in rodent UV-sensitive mutants of group 3, encodes a presumed DNA helicase that is identical to the p89 subunit of the general transcription factor TFIIH/BTF2.
57
Characterization of the mouse homolog of the XPBC/ERCC-3 gene implicated in xeroderma pigmentosum and Cockayne's syndrome.
TL;DR: In this article, the mouse XPBC/ERCC-3 DNA repair gene was isolated and its expression in different tissues and stages of development and to permit the generation of a mouse model of xeroderma pigmentosum (XP) by targeted gene replacement in mouse embryonal stem cells, and a sequence comparison of the predicted protein revealed a 96% amino acid identity with the human gene product.