The present invention relates to peptides, peptide analogs and peptide derivatives related to platelet factor 4 which exhibit anti-inflammatory activity, to pharmaceutical compositions comprising said peptides, and to methods of inhibiting inflammation utilizing the peptides of the invention

Anti-inflammatory peptides

Laboratory evaluation of platelet dysfunction.

Familiarity with disorders of platelet function is imperative because these defects are common causes both of clinical hemorrhage and unexplained bruising and constitute the most common nontechnical cause of surgical bleeding. This article summarizes the acquired and drug-induced platelet function defects with which clinicians and laboratory scientists should be familiar.

Acquired Platelet Function Defects

Heparin released platelet factor 4 in uncomplicated type 1 diabetes mellitus.

Heparin Induced Thrombocytopenia (HIT) is caused by antibodies that recognize platelet factor 4 (PF4) associated with polyanionic glycosaminoglycan drugs or displayed on vascular cell membranes. These antibodies are elicited by multimolecular complexes that can occur when heparin is administered in clinical settings associated with abundant PF4. Heparin binding alters native PF4 and elicits immune recognition and response. While the presence of heparin is integral to immunogenesis, the HIT antibody binding site is within PF4. Thus HIT antibodies develop and function to cause thrombocytopenia and/or thrombosis only in the presence of PF4. Future emphasis on understanding the biology, turnover and regulation of PF4 may lead to insights into the prevention and treatment of HIT.

/pdf/emphasis-on-the-role-of-pf4-in-the-incidence-pathophysiology-3f77hh8txg.pdf

Emphasis on the Role of PF4 in the Incidence, Pathophysiology and Treatment of Heparin Induced Thrombocytopenia

High heparin released platelet factor 4 in uncomplicated type 1 diabetes mellitus.

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High heparin released platelet factor 4 in uncomplicated type 1 diabetes mellitus.