Aim: There is considerable interest in approaches that could improve the therapeutic window of radiotherapy. In this study, hafnium oxide nanoparticles were designed that concentrate in tumor cells to achieve intracellular high-energy dose deposit. Materials & methods: Conventional methods were used, implemented in different ways, to explore interactions of these high-atomic-number nanoparticles and ionizing radiation with biological systems. Results: Using the Monte Carlo simulation, these nanoparticles, when exposed to high-energy photons, were shown to demonstrate an approximately ninefold radiation dose enhancement compared with water. Importantly, the nanoparticles show satisfactory dispersion and persistence within the tumor and they form clusters in the cytoplasm of cancer cells. Marked antitumor activity is demonstrated in human cancer models. Safety is similar in treated and control animals as demonstrated by a broad program of toxicology evaluation. Conclusion: These findings, supported by good ...

Nanoscale radiotherapy with hafnium oxide nanoparticles.

Charged particle therapy has been largely driven and influenced by nuclear physics. The increase in energy deposition density along the ion path in the body allows reducing the dose to normal tissues during radiotherapy compared to photons. Clinical results of particle therapy support the physical rationale for this treatment, but the method remains controversial because of the high cost and of the lack of comparative clinical trials proving the benefit compared to x-rays. Research in applied nuclear physics, including nuclear interactions, dosimetry, image guidance, range verification, novel accelerators and beam delivery technologies, can significantly improve the clinical outcome in particle therapy. Measurements of fragmentation cross-sections, including those for the production of positron-emitting fragments, and attenuation curves are needed for tuning Monte Carlo codes, whose use in clinical environments is rapidly increasing thanks to fast calculation methods. Existing cross sections and codes are indeed not very accurate in the energy and target regions of interest for particle therapy. These measurements are especially urgent for new ions to be used in therapy, such as helium. Furthermore, nuclear physics hardware developments are frequently finding applications in ion therapy due to similar requirements concerning sensors and real-time data processing. In this review we will briefly describe the physics bases, and concentrate on the open issues.

https://iopscience.iop.org/article/10.1088/0034-4885/79/9/096702/pdf

Nuclear physics in particle therapy: a review.

Secondary radiation emission induced by nuclear reactions is correlated to the path of ions in matter. Therefore, such penetrating radiation can be used for in vivo control of hadrontherapy treatments, for which the primary beam is absorbed inside the patient. Among secondary radiations, prompt-gamma rays were proposed for real-time verification of ion range. Such a verification is a desired condition to reduce uncertainties in treatment planning. For more than a decade, efforts have been undertaken worldwide to promote prompt-gamma-based devices to be used in clinical conditions. Dedicated cameras are necessary to overcome the challenges of a broad- and high-energy distribution, a large background, high instantaneous count rates, and compatibility constraints with patient irradiation. Several types of prompt-gamma imaging devices have been proposed, that are either physically-collimated or electronically collimated (Compton cameras). Clinical tests are now undergoing. Meanwhile, other methods than direct prompt-gamma imaging were proposed, that are based on specific counting using either time-of-flight or photon energy measurements. In the present article, we make a review and discuss the state of the art for all techniques using prompt-gamma detection to improve the quality assurance in hadrontherapy.

Prompt-gamma monitoring in hadrontherapy: A review

Experimental observation of cyclotron instabilities in a minimum-B confined electron cyclotron resonance ion source plasma is reported. The instabilities are associated with strong microwave emission and a burst of energetic electrons escaping the plasma, and explain the periodic ms-scale oscillation of the extracted beam currents. Such non-linear effects are detrimental for the confinement of highly charged ions due to plasma perturbations at shorter periodic intervals in comparison with their production time. It is shown that the repetition rate of the periodic instabilities in oxygen plasmas increases with increasing magnetic field strength and microwave power and decreases with increasing neutral gas pressure, the magnetic field strength being the most critical parameter. The occurrence of plasma turbulence is demonstrated to restrict the parameter space available for the optimization of extracted currents of highly charged ions.

https://iopscience.iop.org/article/10.1088/0963-0252/23/2/025020/pdf

Beam current oscillations driven by cyclotron instabilities in a minimum-B electron cyclotron resonance ion source plasma

Silicon photomultipliers (SiPMs) are becoming the reference photodetectors in many fields. In medicine they are slowly replacing photomultiplier tubes and avalanche photodiodes in medical imaging and in PET in particular. In this paper a broad overview of the current applications of SiPM in medicine is presented. The major fields where the SiPMs are used, namely PET/MR and hadrontherapy are discussed at length.

/pdf/medical-applications-of-silicon-photomultipliers-3ibp7mts96.pdf

Medical applications of silicon photomultipliers

Hadrontherapy with protons and carbon ions is a fast developing methodology in radiation oncology. The accelerators used and planned for this purpose are reviewed starting from the cyclotrons used in the thirties. As discussed in the first part of this paper, normal and superconducting cyclotrons are still employed, together with synchrotrons, for proton therapy while for carbon ion therapy synchrotrons have been till now the only option. The latest developments concern a superconducting cyclotron for carbon ion therapy, fast-cycling high frequency linacs and 'single room' proton therapy facilities. These issues are discussed in the second part of the paper by underlining the present challenges, in particular the treatment of moving organs.

Accelerators for hadrontherapy: From Lawrence cyclotrons to linacs

We propose an innovative fast-cycling accelerator complex conceived and designed to exploit at best the properties of accelerated ion beams for hadrontherapy. A cyclinac is composed by a cyclotron, which can be used also for other valuable medical and research purposes, followed by a high gradient linear accelerator capable to produce ion beams optimized for the irradiation of solid tumours with the most modern techniques. The properties of cyclinacs together with design studies for protons and carbon ions are presented and the advantages in facing the challenges of hadrontherapy are discussed.

Cyclinacs: Fast-Cycling Accelerators for Hadrontherapy

http://inspirehep.net/record/813836/files/arXiv:0902.3533.pdf

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Accelerators for hadrontherapy: From Lawrence cyclotrons to linacs

Cyclinacs: Fast-Cycling Accelerators for Hadrontherapy

Cyclinacs: Fast-Cycling Accelerators for Hadrontherapy