G Melling
Oxford Brookes University
5 Papers
9 Citations
G Melling is an academic researcher from Oxford Brookes University. The author has contributed to research in topics: Dental pulp stem cells & Endothelial stem cell. The author has an hindex of 3, co-authored 5 publications. Previous affiliations of G Melling include Cardiff University.
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Papers
The Challenges and Possibilities of Extracellular Vesicles as Therapeutic Vehicles
TL;DR: There are numerous barriers associated with the use of EVs as therapeutic vehicles, including the challenge of efficiently loading therapeutics into EVs, avoiding clearance of the EVs from circulation, targeting the correct tissue type and the inefficiency of internalisation and functional delivery of the cargo.
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Liposomes loaded with transforming growth factor β1 promote odontogenic differentiation of dental pulp stem cells.
Liming Jiang,Liming Jiang,Wayne Nishio Ayre,G Melling,Bing Song,Xiao-Qing Wei,Alastair James Sloan,Xu Chen +7 more
TL;DR: It is indicated that liposomes are an effective carrier for delivering TGF-β1 over time and up-regulated the expression of "osteodentine" markers, RUNX-2, DMP-1 and DSPP, in hDPSCs after 7 days of treatment and resulted in the accumulation of mineralised nodules.
23
Enterococcus faecalis Demonstrates Pathogenicity through Increased Attachment in an Ex Vivo Polymicrobial Pulpal Infection
Wayne Nishio Ayre,G Melling,Camille Cuveillier,Madhan Natarajan,Jessica L Roberts,Lucy Marsh,Christopher D. Lynch,Jean-Yves Maillard,Stephen Paul Denyer,Alastair James Sloan +9 more
TL;DR: The host response to a polymicrobial pulpal infection consisting of Streptococcus anginosus and Enterococcus faecalis, bacteria commonly implicated in dental abscesses and endodontic failure, is investigated using a validated ex vivo rat tooth model, suggesting E. Faecalis pathogenicity in pulpitis is linked to its greater ability to attach to the pulpal vasculature.
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Endothelial Cell-Derived Extracellular Vesicles Elicit Neutrophil Deployment from the Spleen Following Acute Myocardial Infarction
Naveed Akbar,Adam Braithwaite,Emma M Corr,Graeme J. Koelwyn,Coen van Solingen,Clément Cochain,Antoine-Emmanuel Saliba,Alastair L. Corbin,Daniela Pezzolla,Laurienne Edgar,Mala Gunadasa-Rohling,Abhirup Banerjee,Daan Paget,Charlotte Lee,Eleanor Hogg,Adam Costin,Raman Dhaliwal,Errin Johnson,Thomas Krausgruber,Joey Riepsaame,G Melling,Mayooran Shanmuganathan,Christoph Bock,Christoph Bock,David R. F. Carter,Keith M. Channon,Paul R. Riley,Irina A. Udalova,Kathryn J. Moore,Daniel C. Anthony,Robin P. Choudhury +30 more
TL;DR: Injury to the myocardium rapidly mobilises neutrophils from the spleen to peripheral blood and induces their transcriptional activation prior to their arrival at injured tissue, showing a novel mechanism for the rapid mobilisation of neutrophil mobilisation from a splenic reserve, independent of classical chemokine signalling.
Liposomal Delivery of Demineralized Dentin Matrix for Dental Tissue Regeneration.
G Melling,John S. Colombo,Steven J. Avery,Wayne Nishio Ayre,Samuel Lewin Evans,Rachel J. Waddington,Alastair James Sloan +6 more
TL;DR: DDM liposomes were more effective than free DDM at activating recruitment and osteogenic differentiation of DPSC, which are key events in the endogenous repair of the dentin-pulp complex, suggesting that liposomal delivery from biomaterials could be a valuable tool for reparative dentistry and hard-tissue engineering applications.