25 Papers
476 Citations
G. Brun is an academic researcher from International Agency for Research on Cancer. The author has contributed to research in topics: Carcinogen & Ochratoxin. The author has an hindex of 15, co-authored 25 publications.
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Papers
Validation and comparative studies on 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems.
Helmut Bartsch,Christian Malaveille,A.-M. Camus,Ghyslaine Martel-Planche,G. Brun,Agnès Hautefeuille,N. Sabadie,Alain Barbin,T. Kuroki,C. Drevon,C. Piccoli,Ruggero Montesano +11 more
TL;DR: The predictive value of the test, the quantitative relationship between mutagenicity versus electrophilicity versus carcinogenicity of some selected carcinogens, and some factors involved in the efficient detection of mutagens in vitro were analyzed.
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Quantitative comparison of carcinogenicity, mutagenicity and electrophilicity of 10 direct-acting alkylating agents and of the initial O6:7-alkylguanine ratio in DNA with carcinogenic potency in rodents.
Helmut Bartsch,Benedetto Terracini,Christian Malaveille,Lorenzo Tomatis,Jürgen Wahrendorf,G. Brun,Betty Dodet +6 more
TL;DR: Alkylation of guanine at position O6 (or at other O atoms of DNA bases) may be a critical DNA-base modification that determines the overall carcinogenicity of these alkylating agents in rodents.
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Levels of mutagens in the urine of smokers of black and blond tobacco correlate with their risk of bladder cancer
Christian Malaveille,Paolo Vineis,J. Estéve,Hiroshi Ohshima,G. Brun,Agnès Hautefeuille,P. Gallet,G. Ronco,Benedetto Terracini,Helmut Bartsch +9 more
TL;DR: Findings on urinary mutagenicity provide experimental evidence that the type of tobacco is the factor responsible for the observed difference in risk and that smoking of black as compared to blond tobacco results in a higher exposure of the urinary bladder to genotoxic hence potentially carcinogenic substances.
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Immunohistochemical detection of pulmonary cytochrome P450IA and metabolic activities associated with P450IA1 and P450IA2 isozymes in lung cancer patients.
Sisko Anttila,Harri Vainio,Eino Hietanen,Anne-Marie Camus,Christian Malaveille,G. Brun,Kirsti Husgafvel-Pursiainen,Lasse Heikkilä,Antti Karjalainen,Helmut Bartsch +9 more
TL;DR: It is demonstrated that tobacco smoke induces P 450IA1 in the lung and probably P450IA2 in the liver, and a role for certain metabolic phenotypes of P450ia1 in peripheral pulmonary carcinoma is suggested.
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Structure-activity studies in E. coli strains on ochratoxin A (OTA) and its analogues implicate a genotoxic free radical and a cytotoxic thiol derivative as reactive metabolites.
TL;DR: The results implicate an OTA-derived free radical rather than reduced oxygen species as genotoxic intermediate(s) in bacteria.
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